转移性神经母细胞瘤中原发肿瘤的局部控制

Local control of the primary tumour in metastatic neuroblastoma.

作者信息

Sultan Iyad, Ghandour Khalil, Al-Jumaily Usama, Hashem Sameh, Rodriguez-Galindo Carlos

机构信息

Department of Pediatric Oncology, King Hussein Cancer Centre (KHCC), Al-Jubeiha, Amman, Jordan.

出版信息

Eur J Cancer. 2009 Jul;45(10):1728-32. doi: 10.1016/j.ejca.2009.04.021. Epub 2009 May 15.

DOI:10.1016/j.ejca.2009.04.021

PMID:19447607

Abstract

The previous studies have stressed on the importance of loco-regional control in the management of high-risk neuroblastoma. We searched the Surveillance, Epidemiology and End-Results (SEER) database for patients older than 2years with metastatic neuroblastoma who were diagnosed from 1998 to 2005. We identified 291 patients (mean age, 4.35years). The 5-year survival estimate was 53.2%+/-6.4% for patients who had complete resection of their primary tumours (n=116) and 35.7%+/-4.7% for patients who did not have complete resection (p=0.003). External-beam radiotherapy did not affect survival (p=0.79); this finding has to be taken with caution due to the study limitations.

摘要

先前的研究强调了局部区域控制在高危神经母细胞瘤治疗中的重要性。我们在监测、流行病学和最终结果（SEER）数据库中搜索了1998年至2005年诊断为转移性神经母细胞瘤的2岁以上患者。我们确定了291例患者（平均年龄4.35岁）。原发肿瘤完全切除的患者（n = 116）5年生存率估计为53.2%±6.4%，未完全切除的患者为35.7%±4.7%（p = 0.003）。外照射放疗不影响生存率（p = 0.79）；由于研究局限性，这一发现需谨慎看待。