Runge-Samuelson Christina L
Department of Otolaryngology and Communication Sciences, Medical College of Wisconsin, 9200 W. Wisconsin Avenue, Milwaukee, WI 53226, USA.
Trends Amplif. 2009 Jun;13(2):76-86. doi: 10.1177/1084713809336739.
Overcoming issues related to abnormally high neural synchrony in response to electrical stimulation is one aspect in improving hearing with a cochlear implant. Desynchronization of electrical stimuli have shown benefits in neural encoding of electrical signals and improvements in psychophysical tasks. In the present study, 10 participants with either CII or HiRes 90k Advanced Bionics devices were tested for the effects of desynchronizing constant-amplitude high-rate (5,000 Hz) pulse trains on electrode discrimination of sinusoidal stimuli (1,000 Hz). When averaged across the sinusoidal dynamic range, overall improvements in electrode discrimination with high-rate pulses were found for 8 of 10 participants. This effect was significant for the group (p = .003). Nonmonotonic patterns of electrode discrimination as a function of sinusoidal stimulation level were observed. By providing additional spectral channels, it is possible that clinical implementation of constant-amplitude high-rate pulse trains in a signal processing strategy may improve performance with the device.
克服与电刺激时异常高的神经同步性相关的问题是使用人工耳蜗改善听力的一个方面。电刺激去同步化已在电信号的神经编码以及心理物理学任务的改善方面显示出益处。在本研究中，对10名使用CII或HiRes 90k Advanced Bionics设备的参与者测试了恒定幅度高速率（5000赫兹）脉冲序列去同步化对正弦刺激（1000赫兹）电极辨别的影响。当在正弦动态范围内进行平均时，10名参与者中有8名在高速率脉冲下电极辨别总体上有改善。该效应在组水平上具有显著性（p = 0.003）。观察到电极辨别作为正弦刺激水平函数的非单调模式。通过提供额外的频谱通道，在信号处理策略中临床应用恒定幅度高速率脉冲序列有可能改善该设备的性能。
