甲氨蝶呤、类风湿关节炎与感染风险：证据有哪些？
Methotrexate, rheumatoid arthritis and infection risk: what is the evidence?
作者信息
McLean-Tooke Andrew, Aldridge Catherine, Waugh Sheila, Spickett Gavin P, Kay Lesley
机构信息
Department of Immunology, Royal Victoria Infirmary, Newcastle-Upon-Tyne, UK.
出版信息
Rheumatology (Oxford). 2009 Aug;48(8):867-71. doi: 10.1093/rheumatology/kep101. Epub 2009 May 15.
Low-dose MTX administered weekly remains a mainstay in the therapy of RA. There is a belief amongst rheumatologists that RA patients taking MTX have both an increased risk and severity of infection. Here we review the published data on the risks of infection associated with the use of MTX in patients with RA and make some recommendations for managing MTX in patients with infection.
每周使用低剂量甲氨蝶呤仍然是类风湿关节炎治疗的主要手段。风湿病学家普遍认为，服用甲氨蝶呤的类风湿关节炎患者感染风险增加且感染程度更严重。在此，我们回顾已发表的关于类风湿关节炎患者使用甲氨蝶呤相关感染风险的数据，并对感染患者使用甲氨蝶呤的管理提出一些建议。
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