Verduijn Monique M, van den Bemt Bart J F, Dijkmans Ben A C, van der Waal Rutger I F, Horikx Annemieke
Nederlands Huisartsen Genootschap, Utrecht, The Netherlands.
Ned Tijdschr Geneeskd. 2009;153:A695.
Methotrexate (MTX) is an effective medicine that can be safely used for the treatment of rheumatic arthritis and severe cases of psoriasis. For nearly all indications MTX is prescribed as a weekly dose. As a result of prescription errors, miscommunication, failing pharmacovigilance and lack of knowledge, fatal incidents have occurred due to prescriptions for a dosage once daily instead of once weekly. To prevent such incidences in the future, a balanced automatic pharmacovigilance, clear instructions for the use of MTX on the prescription and good patient information are needed.
甲氨蝶呤（MTX）是一种有效的药物，可安全用于治疗风湿性关节炎和严重的银屑病病例。几乎对于所有适应症，MTX均按每周剂量开具处方。由于处方错误、沟通不畅、药物警戒不力和知识匮乏，曾发生过因将剂量开为每日一次而非每周一次而导致的致命事件。为防止未来发生此类事件，需要平衡的自动药物警戒、处方上关于MTX使用的清晰说明以及良好的患者信息。
