Hadeishi H, Yasui N, Suzuki A
Department of Surgical Neurology, Research Institute for Brain and Blood Vessels-Akita.
No Shinkei Geka. 1991 Oct;19(10):945-9.
The risks of surgical treatment for unruptured intracranial aneurysms, as well as the significance of evaluating cerebral blood flow (CBF), are here reported. Out of 72 patients who underwent unruptured aneurysm surgery without such complications as occlusion of the main trunk or perforating arteries, or brain contusion, and who according to CT scans, did not have new lesions related to the operations, 18 patients (25%) developed neurological deficits postoperatively. In 17 of these 18 patients, postoperative neurological deficits (frontal sign: 7, paresis: 4, and seizure: 6 cases) disappeared within 2 weeks following the operations. In the other patient, who was treated for subcortical hematoma in the left temporal lobe before aneurysm surgery, permanent speech disturbance appeared postoperatively. In the 18 patients with postoperative neurological deficits, the mean CBF value (36.2ml/100g/min) was statistically lower than that in the patients (46.2ml/100g/min) who had no postoperative neurological deficits (p less than 0.001). The rate of the patients with lower CBF values who developed postoperative neurological deficits, was statistically higher than that of patients with CBF values greater than 40ml/100g/min (p less than 0.002). In the patients with lower CBF values, common operative procedures for unruptured aneurysms such as craniotomy and mild brain retractions, may damage brain tissue. Careful perioperative management is needed for patients who undergo unruptured aneurysm surgery, because a lower CBF value may represent the degree of brain fragility.
本文报告了未破裂颅内动脉瘤的外科治疗风险以及评估脑血流量(CBF)的意义。在72例接受未破裂动脉瘤手术的患者中,未出现诸如主干或穿支动脉闭塞、脑挫伤等并发症,且根据CT扫描显示,没有与手术相关的新病灶,其中18例患者(25%)术后出现神经功能缺损。在这18例患者中,有17例术后神经功能缺损(额叶体征:7例,轻瘫:4例,癫痫:6例)在术后2周内消失。另1例患者在动脉瘤手术前因左侧颞叶皮质下血肿接受治疗,术后出现永久性言语障碍。在18例有术后神经功能缺损的患者中,平均CBF值(36.2ml/100g/min)在统计学上低于无术后神经功能缺损的患者(46.2ml/100g/min)(p<0.001)。CBF值较低且出现术后神经功能缺损的患者比例,在统计学上高于CBF值大于40ml/100g/min的患者(p<0.002)。对于CBF值较低的患者,未破裂动脉瘤的常见手术操作如开颅和轻度脑牵拉,可能会损伤脑组织。对于接受未破裂动脉瘤手术的患者,需要进行仔细的围手术期管理,因为较低 的CBF值可能代表脑脆弱程度。