Koch M, Uyttenboogaart M, Heersema D, Steen C, De Keyser J
Department of Neurology, University Medical Center Groningen, Postbus 30.001, 9700RB Groningen, The Netherlands.
J Neurol Neurosurg Psychiatry. 2009 Jun;80(6):676-8. doi: 10.1136/jnnp.2008.160911.
Pregnancy has a well-documented effect on relapses in multiple sclerosis (MS), whereas little is known about the impact of pregnancy and childbirth on the risk of secondary progression.
To investigate the association of parity and secondary progression in women with MS.
The association of the number of births and secondary progression was studied in a hospital-based cohort of 277 women with MS. Data were analysed in a multivariable logistic regression model, with adjustment for possible confounders.
Parity was not independently associated with secondary progression, while the factors disease duration (OR per year increase: 1.05, 95% CI 1.03 to 1.09) and use of immunomodulatory treatments (OR 0.23, 95% CI 0.08 to 0.65) were independently associated with secondary progression.
We found no evidence that parity influences the risk of secondary progression in MS. Further population-based studies on the association of pregnancy and childbirth on the long-term prognosis of MS are needed.
怀孕对多发性硬化症（MS）的复发有充分记录的影响，而关于怀孕和分娩对继发进展风险的影响知之甚少。
研究MS女性的生育次数与继发进展之间的关联。
在一个以医院为基础的队列中，对277名MS女性的生育次数与继发进展之间的关联进行了研究。数据在多变量逻辑回归模型中进行分析，并对可能的混杂因素进行了调整。
生育次数与继发进展无独立关联，而疾病持续时间（每年增加的比值比：1.05，95%置信区间1.03至1.09）和免疫调节治疗的使用（比值比0.23，95%置信区间0.08至0.65）与继发进展独立相关。
我们没有发现证据表明生育次数会影响MS继发进展的风险。需要进一步开展基于人群的研究，以探讨怀孕和分娩与MS长期预后之间的关联。
