Kuwayama N, Takaku A, Harada J, Fukuda O, Endo S, Saito T
Department of Neurosurgery, Toyama Medical & Pharmaceutical University, Japan.
Neurosurgery. 1991 Oct;29(4):583-9. doi: 10.1097/00006123-199110000-00017.
A small thermal diffusion flow probe has been developed to monitor the dynamic changes in cerebral blood flow in small animals. Constantan wire was used as a heat source to make a miniature probe. The pair of thermocouples used to detect the heat gradient between two gold plates was elongated to avoid heat conduction between them, and this improvement allowed us to make quantitative measurements. After several basic experiments, local cerebral blood flow was measured simultaneously, using both the modified thermal probe and the hydrogen clearance method in four rabbits. A close relationship was obtained between the local cerebral blood flow values measured by hydrogen clearance (F, ml/100g/min) and the reciprocal of the thermocouple voltage (1/V;1/mV). The regression line was F = 29111(1/V - 1/226), (r = 0.92, P less than 0.001). We suggest that the modified thermal probe is a reliable and quantitative means of measuring flow. In addition, another probe modified for clinical use was evaluated. Continuous monitoring of local cerebral blood flow in postoperative patients was performed, and some illustrative cases are described.
已开发出一种小型热扩散流量探头，用于监测小动物脑血流的动态变化。采用康铜丝作为热源制作微型探头。用于检测两块金板之间热梯度的一对热电偶被拉长，以避免它们之间的热传导，这一改进使我们能够进行定量测量。经过几次基础实验后，在四只兔子身上同时使用改良热探头和氢清除法测量局部脑血流。通过氢清除法测得的局部脑血流值（F，毫升/100克/分钟）与热电偶电压的倒数（1/V；1/毫伏）之间存在密切关系。回归线为F = 29111(1/V - 1/226)，（r = 0.92，P小于0.001）。我们认为改良热探头是一种可靠的定量测量血流的方法。此外，还对另一种改良用于临床的探头进行了评估。对术后患者的局部脑血流进行了连续监测，并描述了一些典型病例。
