Kessenbrock Kai, Krumbholz Markus, Schönermarck Ulf, Back Walter, Gross Wolfgang L, Werb Zena, Gröne Hermann-Josef, Brinkmann Volker, Jenne Dieter E
Department of Neuroimmunology,Max-Planck-Institute of Neurobiology, Martinsried, Germany.
Nat Med. 2009 Jun;15(6):623-5. doi: 10.1038/nm.1959.
Small-vessel vasculitis (SVV) is a chronic autoinflammatory condition linked to antineutrophil cytoplasm autoantibodies (ANCAs). Here we show that chromatin fibers, so-called neutrophil extracellular traps (NETs), are released by ANCA-stimulated neutrophils and contain the targeted autoantigens proteinase-3 (PR3) and myeloperoxidase (MPO). Deposition of NETs in inflamed kidneys and circulating MPO-DNA complexes suggest that NET formation triggers vasculitis and promotes the autoimmune response against neutrophil components in individuals with SVV.
小血管炎（SVV）是一种与抗中性粒细胞胞浆自身抗体（ANCA）相关的慢性自身炎症性疾病。我们在此表明，染色质纤维，即所谓的中性粒细胞胞外诱捕网（NETs），由ANCA刺激的中性粒细胞释放，并包含靶向自身抗原蛋白酶-3（PR3）和髓过氧化物酶（MPO）。NETs在发炎肾脏中的沉积以及循环中的MPO-DNA复合物表明，NET形成触发血管炎并促进SVV患者针对中性粒细胞成分的自身免疫反应。
