Department of Agriculture and Food Systems, University of Melbourne, Royal Parade, Parkville 3010, Australia.
Nat Rev Genet. 2009 Jun;10(6):381-91. doi: 10.1038/nrg2575.
Genome-wide panels of SNPs have recently been used in domestic animal species to map and identify genes for many traits and to select genetically desirable livestock. This has led to the discovery of the causal genes and mutations for several single-gene traits but not for complex traits. However, the genetic merit of animals can still be estimated by genomic selection, which uses genome-wide SNP panels as markers and statistical methods that capture the effects of large numbers of SNPs simultaneously. This approach is expected to double the rate of genetic improvement per year in many livestock systems.
最近，全基因组 SNP 面板已被用于家畜物种，以绘制和识别许多性状的基因，并选择具有遗传优势的家畜。这导致了一些单基因性状的因果基因和突变的发现，但不是复杂性状。然而，通过基因组选择仍然可以估计动物的遗传优势，该方法使用全基因组 SNP 面板作为标记和统计方法，同时捕捉大量 SNP 的影响。这种方法有望使许多家畜系统的遗传改良率每年提高一倍。
