Fritah Asmaà
Institute of Reproductive and Developmental Biology, Imperial College London, Faculty of Medicine, Du Cane Road, London W12 0NN, UK.
Appl Physiol Nutr Metab. 2009 Jun;34(3):362-7. doi: 10.1139/H09-026.
The transcriptional control of metabolism in response to environmental changes plays an important role in energy homeostasis. A number of nuclear receptors control both anabolic and catabolic pathways in metabolic tissues. Their transcriptional activity is mediated by recruitment of coactivators or corepressors to target genes. The corepressor receptor-interacting protein 140 (RIP140) is recruited by many nuclear receptors, including peroxisome proliferator-activated receptors and estrogen-related receptors, and by a number of other transcription factors such as nuclear receptor factor 1. It is responsible for the suppression of gene networks that control catabolism in adipose tissue and skeletal muscle, including glucose uptake, glycolysis, tricarboxylic acid cycle, fatty-acid oxidation, mitochondrial biogenesis, oxidative phosphorylation, and mitochondrial uncoupling. In this review, we focus on the role of RIP140 in regulating energy expenditure and highlight issues to address RIP140 action in skeletal muscle.
代谢对环境变化的转录调控在能量稳态中起着重要作用。许多核受体控制着代谢组织中的合成代谢和分解代谢途径。它们的转录活性是通过将共激活因子或共抑制因子募集到靶基因来介导的。共抑制因子受体相互作用蛋白140（RIP140）被许多核受体募集，包括过氧化物酶体增殖物激活受体和雌激素相关受体，以及许多其他转录因子，如核受体因子1。它负责抑制控制脂肪组织和骨骼肌分解代谢的基因网络，包括葡萄糖摄取、糖酵解、三羧酸循环、脂肪酸氧化、线粒体生物发生、氧化磷酸化和线粒体解偶联。在这篇综述中，我们聚焦于RIP140在调节能量消耗中的作用，并突出解决RIP140在骨骼肌中作用的相关问题。
