Institute of Reproductive and Developmental Biology, Imperial College London, UK.
Am J Physiol Endocrinol Metab. 2010 Sep;299(3):E335-40. doi: 10.1152/ajpendo.00243.2010. Epub 2010 Jun 8.
RIP140 is a transcriptional coregulator highly expressed in metabolic tissues where it has important and diverse actions. RIP140-null mice show that it plays a crucial role in the control of lipid metabolism in adipose tissue, skeletal muscle, and the liver and is essential for female fertility. RIP140 has been shown to act as a ligand-dependent transcriptional corepressor for metabolic nuclear receptors such as estrogen-related receptors and peroxisome proliferator-activated receptors. The role of RIP140 as a corepressor has been strengthened by the characterization of RIP140-overexpressing mice, although it emerges through several studies that RIP140 can also behave as a coactivator. Nuclear localization of RIP140 is important for controlling transcription of target genes and is subject to regulation by posttranslational modifications. However, cytoplasmic RIP140 has been shown to play a role in the control of metabolism through direct regulation of glucose transport in adipocytes. In this review, we focus on recent advances highlighting the growing importance of RIP140 as a regulator of energy homeostasis.
RIP140 是一种在代谢组织中高度表达的转录共调节因子，它在其中具有重要且多样化的作用。RIP140 敲除小鼠表明，它在脂肪组织、骨骼肌和肝脏中脂质代谢的控制中起着至关重要的作用，并且对于雌性生育能力是必不可少的。已经表明，RIP140 作为代谢核受体（如雌激素相关受体和过氧化物酶体增殖物激活受体）的配体依赖性转录共抑制因子发挥作用。尽管通过几项研究表明 RIP140 也可以作为共激活因子发挥作用，但 RIP140 过表达小鼠的特征进一步加强了 RIP140 作为共抑制因子的作用。RIP140 的核定位对于控制靶基因的转录很重要，并受到翻译后修饰的调节。然而，已经表明细胞质 RIP140 通过直接调节脂肪细胞中的葡萄糖转运在代谢控制中发挥作用。在这篇综述中，我们重点介绍了最近的进展，强调了 RIP140 作为能量平衡调节剂的重要性日益增加。
