Scapellato Pablo Gustavo, Bottaro Edgardo Gabriel, Rodríguez-Brieschke María Teresa
Servicio Infectología, Hospital Donación F Santojanni, Buenos Aires, Argentina.
Rev Soc Bras Med Trop. 2009 Mar-Apr;42(2):107-9. doi: 10.1590/s0037-86822009000200002.
A study was conducted on all newborns from mothers with Chagas disease who were attended at Hospital Donación F. Santojanni between January 1, 2001, and August 31, 2007. Each child was investigated for the presence of Trypanosoma cruzi parasitemia through direct examination of blood under the microscope using the buffy coat method on three occasions during the first six months of life. Serological tests were then performed. Ninety-four children born to mothers infected with Trypanosoma cruzi were attended over the study period. Three of these children were born to mothers coinfected with the human immunodeficiency virus. Vertical transmission of Chagas disease was diagnosed in 13 children, in all cases by identifying parasitemia. The overall Chagas disease transmission rate was 13.8% (13/94). It was 100% (3/3) among the children born to mothers with HIV infection and 10.9% (10/91) among children born to mothers without HIV [Difference = 0.89; CI95 = 0.82-0.95; p = 0.0021]. We concluded that coinfection with HIV could increase the risk of vertical transmission of Chagas disease.
对2001年1月1日至2007年8月31日期间在多纳ción F.桑托亚尼医院就诊的恰加斯病母亲所生的所有新生儿进行了一项研究。在每个孩子生命的前六个月内，分三次使用血沉棕黄层法通过显微镜直接检查血液，以调查是否存在克氏锥虫血症。然后进行血清学检测。在研究期间，有94名感染克氏锥虫的母亲所生的孩子接受了检查。其中3名儿童的母亲同时感染了人类免疫缺陷病毒。在13名儿童中诊断出恰加斯病垂直传播，所有病例均通过识别寄生虫血症确诊。恰加斯病的总体传播率为13.8%（13/94）。感染艾滋病毒母亲所生儿童中的传播率为100%（3/3），未感染艾滋病毒母亲所生儿童中的传播率为10.9%（10/91）[差异=0.89；95%CI=0.82 - 0.95；p = 0.0021]。我们得出结论，合并感染艾滋病毒可能会增加恰加斯病垂直传播的风险。
