Dong Jin-Tang, Chen Ceshi
Department of Hematology and Medical Oncology, Department of Urology and Winship Cancer Institute, Emory University School of Medicine, 1365-C Clifton Road, Atlanta, GA 30322, USA.
Cell Mol Life Sci. 2009 Aug;66(16):2691-706. doi: 10.1007/s00018-009-0045-z. Epub 2009 May 16.
KLF5 (Kruppel-like factor 5) is a basic transcription factor binding to GC boxes at a number of gene promoters and regulating their transcription. KLF5 is expressed during development and, in adults, with higher levels in proliferating epithelial cells. The expression and activity of KLF5 are regulated by multiple signaling pathways, including Ras/MAPK, PKC, and TGFbeta, and various posttranslational modifications, including phosphorylation, acetylation, ubiquitination, and sumoylation. Consistently, KLF5 mediates the signaling functions in cell proliferation, cell cycle, apoptosis, migration, differentiation, and stemness by regulating gene expression in response to environment stimuli. The expression of KLF5 is frequently abnormal in human cancers and in cardiovascular disease-associated vascular smooth muscle cells (VSMCs). Due to its significant functions in cell proliferation, survival, and differentiation, KLF5 could be a potential diagnostic biomarker and therapeutic target for cancer and cardiovascular diseases.
KLF5（Kruppel样因子5）是一种碱性转录因子，可与多个基因启动子处的GC盒结合并调节其转录。KLF5在发育过程中表达，在成体中，在增殖的上皮细胞中表达水平更高。KLF5的表达和活性受多种信号通路调节，包括Ras/MAPK、PKC和TGFβ，以及各种翻译后修饰，包括磷酸化、乙酰化、泛素化和SUMO化。一致地，KLF5通过响应环境刺激调节基因表达，介导细胞增殖、细胞周期、凋亡、迁移、分化和干性中的信号功能。KLF5的表达在人类癌症以及与心血管疾病相关的血管平滑肌细胞（VSMC）中经常异常。由于其在细胞增殖、存活和分化中的重要功能，KLF5可能是癌症和心血管疾病的潜在诊断生物标志物和治疗靶点。
