BACKGROUND: Metabolic reprogramming is critical in cardiovascular disease (CVD) research, affecting a variety of diseases such as myocardial damage, coronary heart disease, and atherosclerosis, and has also emerged as a therapeutic target. This study conducts a bibliometric analysis of the past 24 years to identify trends and hotspots in CVD metabolism, aiming to guide future research and inform policy. METHODS: This study analyzes publications from January 1, 2000, to October 10, 2024, using the Web of Science Core Collection database. Tools like CiteSpace, VOSviewer, and SCImago Graphica were used for co-authorship, keyword, citation, and journal visualizations. Dual-map overlays and annual publication trends were examined to uncover hotspots, trends, and the progression of metabolic reprogramming in CVD. RESULTS: This study analyzed 765 articles and reviews from 66 countries. The USA had the most publications, with the University of Milan being the most productive institution. Després, JP's team in Italy, published the most papers. The International Journal of Molecular Sciences had the highest publication count, while Cardiovascular Diabetology had the greatest citation impact. Recent research has mainly focused on the role of immune cell substrate metabolism in CVD. CONCLUSION: This study reveals the development trend and research characteristics of CVD metabolic reprogramming over the past 24 years, from the early focus on disease risk factors to the recent exploration of the transformation of immune cell metabolism. In the future, targeting immune cell metabolism will drive CVD therapy forward.