Schuster David M, Nye Jonathon A, Nieh Peter T, Votaw John R, Halkar Raghuveer K, Issa Muta M, Yu Weiping, Sepulveda Julio, Zeng Wanzhen, Young Andrew, Goodman Mark M
Department of Radiology, Division of Nuclear Medicine, Emory University, Atlanta, GA 30322, USA.
Mol Imaging Biol. 2009 Nov-Dec;11(6):434-8. doi: 10.1007/s11307-009-0220-5. Epub 2009 May 16.
Assessment of renal masses with conventional imaging may be challenging. Anti-1-amino-3-[(18)F]fluorocyclobutane-1-carboxylic acid (anti-[18F]FACBC) is a synthetic L: -leucine analog with relatively little renal excretion. The present study examines anti-[(18)F]FACBC positron emission tomography uptake in patients with renal masses.
Six patients with seven renal lesions were imaged dynamically for 2 h after injection of 10-10.9 mCi (370-403 MBq) anti-[(18)F]FACBC. Lesions were evaluated qualitatively and quantitatively and correlated with histology.
Four clear cell and one Rosai-Dorfman lesion were hypo/isointense to normal cortex; two papillary lesions in the same patient were hyperintense. Mean SUV(max) +/- SD at 30 min was 2.8 +/- 0.24 for clear cell carcinomas and 4.5 +/- 1.7 for papillary cell lesions. Mean SUV(max)/SUV(mean) ratios +/- SD of lesion to normal cortex at 30 min was 1.15 +/- 0.19 for the clear cell carcinomas and 2.3 +/- 0.84 for papillary cell.
In this small patient sample, relative amino acid transport compared with renal cortex is elevated in renal papillary cell carcinoma but not in clear cell carcinoma.
用传统成像方法评估肾肿块可能具有挑战性。抗1-氨基-3-[(18)F]氟环丁烷-1-羧酸（抗-[18F]FACBC）是一种合成的L-亮氨酸类似物，肾排泄相对较少。本研究检测肾肿块患者中抗-[(18)F]FACBC正电子发射断层扫描的摄取情况。
6例患有7个肾病变的患者在注射10 - 10.9 mCi（370 - 403 MBq）抗-[(18)F]FACBC后进行了2小时的动态成像。对病变进行定性和定量评估，并与组织学进行关联。
4例透明细胞癌和1例罗萨伊-多夫曼病变相对于正常皮质呈低/等密度；同一患者的2例乳头状病变呈高密度。透明细胞癌在30分钟时的平均SUV(max)±标准差为2.8±0.24，乳头状细胞病变为4.5±1.7。透明细胞癌在30分钟时病变与正常皮质的平均SUV(max)/SUV(mean)比值±标准差为1.15±0.19，乳头状细胞病变为2.3±0.84。
在这个小样本患者中，与肾皮质相比，肾乳头状细胞癌中相对氨基酸转运升高，而透明细胞癌中未升高。
