Kuschinsky W
Department of Physiology, University of Heidelberg, Fed. Rep. of Germany.
Neurosurg Rev. 1991;14(3):163-8. doi: 10.1007/BF00310651.
Functional activity, metabolism and blood flow are locally heterogeneous in the brain, but tightly coupled. This adjustment occurs in two different ways: 1. Short-term, dynamic coupling mediated by local vasoactive factors that ensure second-to-second regulation. 2. Long-term, static coupling apparently mediated by capillary density and developed in response to local functional and metabolic activity. Recognizing these two mechanisms permits one to distinguish apparent from real uncoupling. It allows the conclusion that there is no indication of an uncoupling of metabolism and blood flow during physiological conditions.
大脑中的功能活动、代谢和血流在局部是异质性的，但紧密耦合。这种调节以两种不同方式发生：1. 由局部血管活性因子介导的短期动态耦合，确保逐秒调节。2. 长期静态耦合，显然由毛细血管密度介导，并响应局部功能和代谢活动而形成。认识到这两种机制可以使人区分表观解耦和真正的解耦。由此可以得出结论，在生理条件下，没有代谢与血流解耦的迹象。
