Kuschinsky W, Suda S, Sokoloff L
J Cereb Blood Flow Metab. 1985 Mar;5(1):58-64. doi: 10.1038/jcbfm.1985.8.
The relationship between local cerebral glucose utilization (LCGU) and local CBF (LCBF) was examined during the action of gamma-hydroxybutyrate (GHB) (900 mg/kg i.v.) in conscious rats. GHB induced discrepant effects on blood flow and metabolism. LCGU was markedly depressed in all structures examined, whereas LCBF was differently affected in that no related changes were observed. Global glucose utilization was markedly depressed (-51%), whereas global blood flow was not significantly altered. The marked dissociation between the changes in global glucose utilization and global blood flow induced by GHB is reflected only to a minor degree in the local values inasmuch as the correlation between LCGU and LCBF was only slightly weakened and its heterogeneity was increased.
在清醒大鼠静脉注射γ-羟基丁酸（GHB，900mg/kg）过程中，研究了局部脑葡萄糖利用（LCGU）与局部脑血流量（LCBF）之间的关系。GHB对血流和代谢产生了不同的影响。在所检查的所有结构中，LCGU均显著降低，而LCBF受到的影响不同，未观察到相关变化。整体葡萄糖利用显著降低（-51%），而整体血流量未显著改变。GHB引起的整体葡萄糖利用变化与整体血流量变化之间的显著分离仅在局部值中得到轻微体现，因为LCGU与LCBF之间的相关性仅略有减弱，且其异质性增加。
