Liu Cong-Rong, Li Man-Bo, Cheng Dao-Juan, Yang Cui-Feng, Tian Shi-Kai
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, China.
Org Lett. 2009 Jun 18;11(12):2543-5. doi: 10.1021/ol900788r.
An unprecedented catalyst-free alkylation of sulfinic acids with sulfonamides has been developed via sp(3) C-N bond cleavage at room temperature. In the absence of external catalysts and additives, a wide variety of N-benzylic and N-allylic sulfonamides couple with sulfinic acids to give structurally diversified sulfones in moderate to excellent yields. Furthermore, the reaction of N-(2-acyl)allylic sulfonamides with sulfinic acids provides a convenient access to trisubstituted allyl sulfones with exclusive Z selectivity.
通过室温下的sp(3)C-N键裂解，开发了一种前所未有的无催化剂的亚磺酸与磺酰胺的烷基化反应。在没有外部催化剂和添加剂的情况下，多种N-苄基和N-烯丙基磺酰胺与亚磺酸偶联，以中等至优异的产率得到结构多样的砜。此外，N-(2-酰基)烯丙基磺酰胺与亚磺酸的反应为选择性地制备具有Z构型的三取代烯丙基砜提供了一条便捷途径。
