Charitidi Konstantina, Meltser Inna, Tahera Yeasmin, Canlon Barbara
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Hear Res. 2009 Jun;252(1-2):71-8. doi: 10.1016/j.heares.2008.12.009. Epub 2009 Jan 22.
Recently significant progress was made in understanding the mechanisms by which the two estrogen receptors (alpha and beta) are involved in different pathways of estrogen action in a wide variance of tissues. Divergent responses of cells and tissues to estrogens or their ligands have been attributed to various isoforms and signaling pathways of estrogen receptors. Both subtypes of estrogen receptors have been identified in the cochlea and there are indications that they have neuroprotective effects but there is still limited information on the role and specific mechanisms of these two receptors in the auditory system. This review will examine the molecular and functional actions of the two estrogen receptor subtypes, the pivotal role they play in the auditory system and their therapeutic strategies for protecting against hearing loss.
最近，在理解两种雌激素受体（α和β）参与多种组织中雌激素作用的不同途径的机制方面取得了重大进展。细胞和组织对雌激素或其配体的不同反应归因于雌激素受体的各种亚型和信号通路。在耳蜗中已鉴定出两种雌激素受体亚型，有迹象表明它们具有神经保护作用，但关于这两种受体在听觉系统中的作用和具体机制的信息仍然有限。本综述将探讨两种雌激素受体亚型的分子和功能作用、它们在听觉系统中所起的关键作用以及它们预防听力损失的治疗策略。
