van Dorp Suzanne, Pietersma Floor, Wölfl Matthias, Verdonck Leo F, Petersen Eefke J, Lokhorst Henk M, Martens Edwin, Theobald Matthias, van Baarle Debbie, Meijer Ellen, Kuball Jürgen
Department of Hematology and Van Creveld Clinic, UMC Utrecht, The Netherlands.
Biol Blood Marrow Transplant. 2009 Jun;15(6):671-8. doi: 10.1016/j.bbmt.2009.02.005. Epub 2009 Apr 16.
Chronic graft-versus-host-disease (cGVHD) is the major cause of late morbidity and mortality after allogeneic stem cell transplantation. B cells have been reported to be involved in mediating cGVHD. To assess whether preemptive host B cell depletion prevents extensive cGVHD after allogeneic reduced-intensity conditioning transplantation (RICT), 173 patients treated with RICT for various hematologic diseases, who had or had not received Rituximab (Rtx) within 6 month prior to RICT, were analyzed retrospectively. Rtx treatment within 6 months prior to RICT reduced extensive cGVHD significantly from 45.8% to 20.1%. We hypothesize that most likely host B cells initiate cGVHD, and thus, host B cell depletion prior to RICT by Rtx might be a valuable strategy to reduce extensive cGVHD after RICT.
慢性移植物抗宿主病（cGVHD）是异基因干细胞移植后晚期发病和死亡的主要原因。据报道，B细胞参与介导cGVHD。为了评估在异基因减低强度预处理移植（RICT）后，抢先性清除宿主B细胞是否能预防广泛的cGVHD，我们回顾性分析了173例因各种血液系统疾病接受RICT治疗的患者，这些患者在RICT前6个月内接受或未接受利妥昔单抗（Rtx）治疗。RICT前6个月内接受Rtx治疗可使广泛cGVHD的发生率从45.8%显著降至20.1%。我们推测，很可能是宿主B细胞引发了cGVHD，因此，在RICT前通过Rtx清除宿主B细胞可能是减少RICT后广泛cGVHD的一种有价值的策略。
