Qureshi Muddasir, Brown Robert H, Rogers Jack T, Cudkowicz Merit E
Neurology Clinical Trials Unit; Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, 02129, USA.
Open Neurol J. 2008 Sep 12;2:51-4. doi: 10.2174/1874205X00802010051.
Metal toxicity has been identified as a possible risk factor for amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. We conducted a retrospective chart review of urinary, hair and blood metal levels and serum ferritin in 321 people with ALS seen over a ten-year period at the Massachusetts General Hospital (MGH). We found that hair lead levels and serum ferritin levels were elevated in ALS patients compared to published normal values. Metal levels of arsenic, lead, mercury, cadmium, thallium, cobalt and aluminum in 24-hour urine specimens and lead, mercury and arsenic in serum were within the normal range. We conclude that twenty-four hour urine or blood testing for metals is not warranted as part of the evaluation of ALS. Elevated levels of serum ferritin in ALS population could reflect an underlying perturbation in iron metabolism.
金属毒性已被确认为肌萎缩侧索硬化症（ALS）和其他神经退行性疾病的一个潜在风险因素。我们对在十年期间于麻省总医院（MGH）就诊的321例ALS患者的尿液、头发和血液中的金属水平以及血清铁蛋白进行了回顾性病历审查。我们发现，与已公布的正常值相比，ALS患者的头发铅水平和血清铁蛋白水平有所升高。24小时尿液样本中的砷、铅、汞、镉、铊、钴和铝以及血清中的铅、汞和砷的金属水平均在正常范围内。我们得出结论，作为ALS评估的一部分，没有必要进行24小时尿液或血液金属检测。ALS人群中血清铁蛋白水平升高可能反映了铁代谢的潜在紊乱。
