Wang Lan, Li Chunyu, Chen Xueping, Li Shuying, Shang Huifang
Department of Neurology, West China Hospital, Sichuan University, Chengdu, China.
Front Neurol. 2020 May 20;11:380. doi: 10.3389/fneur.2020.00380. eCollection 2020.
In recent years, the role of iron metabolism in amyotrophic lateral sclerosis (ALS) attracts more and more attention, and some studies have focused on the link between abnormal serum iron indicators and ALS. However, there are still big conflicts and inconsistency among different studies. To study the possible relationship between ALS and disturbed iron metabolism, we conducted this meta-analysis to conclude characteristics of abnormal serum iron-status indicator changes in ALS patients. We searched and screened main databases, including the PubMed, Embase, and Cochrane Library, to find studies related to the association between iron metabolism and ALS. The Revman 5.3 software was used to conduct meta-analysis. Eleven studies were finally included in our analysis, composed of 1,599 ALS patients and 1,255 controls in total. The results showed that the ferritin level was much higher in ALS patients compared with controls (MD = 70.48, 95% CI [51.41, 89.55], < 0.00001), and the transferrin level was decreased in ALS patients compared with controls (SMD = -0.28, 95% CI [-0.38, -0.18], < 0.00001), while there was no statistical difference in iron levels (SMD = 0.48, 95% CI [-0.07, 1.03], = 0.09) between ALS patients and controls. Our research finds unusual changes in several indicators representing iron status, which suggest possible iron metabolism abnormalities in ALS patients. That may provide evidence for the link between iron metabolism and the pathogenesis of ALS.
近年来，铁代谢在肌萎缩侧索硬化症（ALS）中的作用越来越受到关注，一些研究聚焦于血清铁指标异常与ALS之间的联系。然而，不同研究之间仍存在较大冲突和不一致性。为了研究ALS与铁代谢紊乱之间的可能关系，我们进行了这项荟萃分析，以总结ALS患者血清铁状态指标异常变化的特征。我们检索并筛选了主要数据库，包括PubMed、Embase和Cochrane图书馆，以查找与铁代谢和ALS关联相关的研究。使用Revman 5.3软件进行荟萃分析。最终有11项研究纳入我们的分析，总共包括1599例ALS患者和1255例对照。结果显示，与对照组相比，ALS患者的铁蛋白水平显著更高（MD = 70.48，95%CI[51.41, 89.55]，< 0.00001），与对照组相比，ALS患者的转铁蛋白水平降低（SMD = -0.28，95%CI[-0.38, -0.18]，< 0.00001），而ALS患者与对照组之间的铁水平无统计学差异（SMD = 0.48，95%CI[-0.07, 1.03]，= 0.09）。我们的研究发现了代表铁状态的几个指标的异常变化，这表明ALS患者可能存在铁代谢异常。这可能为铁代谢与ALS发病机制之间的联系提供证据。
