邻双胍基苯与砷酸和磷酸在溶液和固态中的络合能力，以及它们的固定化衍生物作为金属盐和砷酸的固体碱配体的潜在用途。

Complexability of o-bisguanidinobenzenes with arsenic and phosphoric acids in solution and solid states, and the potential use of their immobilized derivatives as solid base ligands for metal salts and arsenic acid.

机构信息

Department of Medicinal Organic Chemistry, Graduate School of Pharmaceutical Sciences, Chiba University, 1-33 Yayoi, Inage, Chiba, 263-8522, Japan.

出版信息

Mol Divers. 2010 Feb;14(1):131-45. doi: 10.1007/s11030-009-9155-7. Epub 2009 May 19.

DOI:10.1007/s11030-009-9155-7

PMID:19452258

Abstract

The role of o-bisguanidinobenzenes (BGBs) as new Brønsted base ligands for arsenic and phosphoric acids was examined. In solution state, complexation was evaluated by Job's plot in (1)H NMR experiment, indicating a 1:1 complex formation, whereas in solid state crystalline structures of complexes obtained were addressed by X-ray crystallographic analysis and/or solid state (13)C NMR experiment, in which 1:2 complexes between the BGB and the acid components were normally formed. Based on these results, Merrifield and Hypogel resin-anchored BGBs were designed and prepared as the corresponding polymer-supported host ligands. Evaluation of their coordination ability with metal salts (ZnCl(2) and CoCl(2)) and arsenic acid in aqueous media by ICP-MS showed that the latter Hypogel resin-anchored BGBs acted as effective immobilized base ligands.

摘要

研究了 o-双胍基苯（BGB）作为新型 Brønsted 碱配体与砷酸和磷酸的配位作用。在溶液状态下，通过（1）H NMR 实验中的 Job 作图评估配合物的形成，表明形成了 1:1 的配合物，而在固态中，通过 X 射线晶体结构分析和/或固态（13）C NMR 实验确定了获得的配合物的晶体结构，其中通常形成 BGB 和酸组分之间的 1:2 配合物。基于这些结果，设计并制备了 Merrifield 和 Hypogel 树脂固载 BGB 作为相应的聚合物负载的主体配体。通过 ICP-MS 评价它们在水介质中与金属盐（ZnCl（2）和 CoCl（2））和砷酸的配位能力，结果表明后者 Hypogel 树脂固载的 BGB 作为有效的固定化碱配体。