Molnár L, Burger T, Schmelczer M, Fábián G
Pécsi Orvostudományi Egyetem II. sz. Belgyógyászati Klinika.
Orv Hetil. 1991 Oct 20;132(42):2299-302.
Myelodysplastic syndrome is a clonal stem-cell disease, which predominantly involves myeloid cell lines. However, several observations refer to a possible pathological condition of the lymphoid system as well. Because of these controversial data, we investigated 25 patients with MDS at our clinic. Absolute lymphocyte counts, lymphocyte subpopulations (using methods of mAT, OKT 3, 4, 8, Leu7), T and B rosette tests and quantitative tests of immunoglobulins were made possibly during diagnosis or breaks in treatment. A significant ratio of our patients had lymphopenie. Using both rosette tests or mAT methods, the ratio of T-cells (primarily of T4-cells) reduced, and the decrease of NK-cells characterized with Leu7 mAT was also marked. Polyclonal hypergammaglobulinaemia could frequently and significantly be observed during immunoglobulin identification. All the observed abnormalities were rather marked in the group of patients with excess of blasts.
骨髓增生异常综合征是一种克隆性干细胞疾病，主要累及髓系细胞系。然而，一些观察结果也提到了淋巴系统可能存在的病理状况。由于这些有争议的数据，我们对我院门诊的25例骨髓增生异常综合征患者进行了调查。在诊断期间或治疗间隙尽可能进行绝对淋巴细胞计数、淋巴细胞亚群分析（采用mAT、OKT 3、4、8、Leu7方法）、T和B玫瑰花结试验以及免疫球蛋白定量检测。我们的患者中有相当比例存在淋巴细胞减少。使用玫瑰花结试验或mAT方法时，T细胞（主要是T4细胞）比例降低，用Leu7 mAT检测的NK细胞减少也很明显。在免疫球蛋白鉴定过程中经常能明显观察到多克隆高球蛋白血症。所有观察到的异常在原始细胞增多的患者组中都相当明显。
