Evans David
Southmead Hospital, Bristol, UK.
BMJ Clin Evid. 2007 Jun 1;2007:0319.
About 50% of term and 80% of preterm babies develop jaundice, which usually appears 2-4 days after birth, and resolves spontaneously after 1-2 weeks. Jaundice is caused by bilirubin deposition in the skin. Most jaundice in newborn infants is a result of increased red cell breakdown and decreased bilirubin excretion.
We conducted a systematic review and aimed to answer the following clinical questions: What are the effects of treatments for unconjugated hyperbilirubinaemia in term and preterm infants? We searched: Medline, Embase, The Cochrane Library and other important databases up to November 2006 (BMJ Clinical evidence reviews are updated periodically, please check our website for the most up-to-date version of this review). We included harms alerts from relevant organisations such as the US Food and Drug Administration (FDA) and the UK Medicines and Healthcare products Regulatory Agency (MHRA).
We found 14 systematic reviews, RCTs, or observational studies that met our inclusion criteria. We performed a GRADE evaluation of the quality of evidence for interventions.
In this systematic review we present information relating to the effectiveness and safety of the following interventions: albumin infusion, exchange transfusion, home phototherapy, hospital phototherapy, tin-mesoporphyrin.
约50%的足月儿和80%的早产儿会出现黄疸，黄疸通常在出生后2 - 4天出现，并在1 - 2周后自行消退。黄疸是由胆红素在皮肤中沉积引起的。大多数新生儿黄疸是红细胞分解增加和胆红素排泄减少的结果。
我们进行了一项系统评价，旨在回答以下临床问题：足月儿和早产儿未结合型高胆红素血症的治疗效果如何？我们检索了：截至2006年11月的Medline、Embase、Cochrane图书馆及其他重要数据库（BMJ临床证据综述会定期更新，请查看我们的网站获取本综述的最新版本）。我们纳入了来自美国食品药品监督管理局（FDA）和英国药品和医疗产品监管局（MHRA）等相关组织的危害警示。
我们发现14项符合我们纳入标准的系统评价、随机对照试验或观察性研究。我们对干预措施的证据质量进行了GRADE评估。
在本系统评价中，我们呈现了以下干预措施的有效性和安全性相关信息：白蛋白输注、换血疗法、家庭光疗、医院光疗、锡-中卟啉。
