温度敏感型可生物降解聚乙二醇

Temperature-sensitive biodegradable poly(ethylene glycol).

作者信息

Lee Jisun, Joo Min Kyung, Kim Jinheung, Park Jong Sang, Yoon Moon-Young, Jeong Byeongmoon

机构信息

Department of Chemistry, Division of Nano Sciences, Ewha Womans University, Seoul 120-750, South Korea.

出版信息

J Biomater Sci Polym Ed. 2009;20(7-8):957-65. doi: 10.1163/156856209X444367.

DOI:10.1163/156856209X444367

PMID:19454162

Abstract

We report here that the incorporation of several disulfide bonds along poly(ethylene glycol) (PEG) gives temperature sensitivity, as well as biodegradability to PEG. To synthesize a PEG with temperature sensitivity in a physiologically important range (20-40 degrees C), PEGs with molecular masses of 400 and 600 Da were randomly coupled by disulfide bonds. As the mol ratio of PEG (400 Da) disulfide to PEG (600 Da) disulfide increased from 40:60 to 60:40, the cloud point of the polymer aqueous solution decreased from 35 degrees C to 27 degrees C. The disulfide bonds between PEGs were degraded in the presence of a thiol-containing biomolecule of glutathione in a thiol-concentration-dependent manner.

摘要

我们在此报告，在聚乙二醇（PEG）中引入多个二硫键可赋予其温度敏感性以及生物降解性。为了合成在生理重要温度范围（20 - 40摄氏度）具有温度敏感性的PEG，将分子量为400和600 Da的PEG通过二硫键随机偶联。随着PEG（400 Da）二硫键与PEG（600 Da）二硫键的摩尔比从40:60增加到60:40，聚合物水溶液的浊点从35摄氏度降至27摄氏度。PEG之间的二硫键在含谷胱甘肽的含硫醇生物分子存在下以硫醇浓度依赖性方式降解。