Tarasevich B J, Gutowska A, Li X S, Jeong B-M
Pacific Northwest National Laboratory-Materials Science, Richland, Washington 99352, USA.
J Biomed Mater Res A. 2009 Apr;89(1):248-54. doi: 10.1002/jbm.a.32025.
Graft copolymers consisting of a poly(D,L-lactic acid-co-glycolic acid) backbone grafted with polyethylene glycol side chains were synthesized and formed thermoreversible gels in aqueous solutions that exhibited solution behavior at low temperature and sol-to-gel transitions at higher temperature. The composition of the polymer and relative amounts of polylactic acid, glycolic acid, and ethylene glycol were varied by controlling the precursor concentrations and reaction temperature. The gelation temperature could be systematically tailored from 15 to 34 degrees C by increasing the concentration of polyethylene glycol in the graft copolymer. The gelation temperature also depended on the polymer molecular weight and concentration. This work has importance for the development of water soluble gels with tailored compositions and gelation temperatures for use in tissue engineering and as injectable depots for drug delivery.
合成了由接枝有聚乙二醇侧链的聚（D，L-乳酸-共-乙醇酸）主链组成的接枝共聚物，该接枝共聚物在水溶液中形成热可逆凝胶，在低温下表现出溶液行为，在较高温度下发生溶胶-凝胶转变。通过控制前体浓度和反应温度，可以改变聚合物的组成以及聚乳酸、乙醇酸和乙二醇的相对含量。通过增加接枝共聚物中聚乙二醇的浓度，凝胶化温度可以系统地从15℃调整到34℃。凝胶化温度还取决于聚合物的分子量和浓度。这项工作对于开发具有定制组成和凝胶化温度的水溶性凝胶具有重要意义，这些凝胶可用于组织工程以及作为药物递送的可注射储库。
