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通过有机催化剂非共晶混合物（NEMO）制备一种模拟且可降解的聚乙二醇——一锅两步法。

Preparation of a mimetic and degradable poly(ethylene glycol) by a non-eutectic mixture of organocatalysts (NEMO) a one-pot two-step process.

作者信息

Moins S, Loyer P, Odent J, Coulembier O

机构信息

Laboratory of Polymeric and Composite Materials, Center of Innovation and Research in Materials and Polymers (CIRMAP), University of Mons (UMons) Place du Parc 23 7000 Mons Belgium

Inserm, INRA, Univ Rennes, Institut NUMECAN (Nutrition Metabolisms and Cancer) UMR-A 1341 UMR S 1241 F-35000 Rennes France.

出版信息

RSC Adv. 2019 Dec 4;9(68):40013-40016. doi: 10.1039/c9ra09781c. eCollection 2019 Dec 2.

DOI:10.1039/c9ra09781c
PMID:35541396
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9076182/
Abstract

A one-pot, two-step method for the preparation of degradable PEG is here presented. The full process addresses the requirements imposed by green chemistry and involves the use of a single and nontoxic non-eutectic mixture of organocatalysts. The strategy relies on the polycondensation of PEG800 after its functionalization by bio-derived 5-membered γ-butyrolactone.

摘要

本文提出了一种一锅两步法制备可降解聚乙二醇（PEG）的方法。整个过程满足了绿色化学的要求，且使用了单一无毒的非共晶有机催化剂混合物。该策略基于生物衍生的五元γ-丁内酯对PEG800进行功能化后再进行缩聚反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/5eccda93474f/c9ra09781c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/e28fd1952a38/c9ra09781c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/e3d8b4212c44/c9ra09781c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/38ce5e2a2825/c9ra09781c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/070504fd5d0a/c9ra09781c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/007fc566ef9c/c9ra09781c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/5eccda93474f/c9ra09781c-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/e28fd1952a38/c9ra09781c-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/e3d8b4212c44/c9ra09781c-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/38ce5e2a2825/c9ra09781c-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/070504fd5d0a/c9ra09781c-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/007fc566ef9c/c9ra09781c-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6408/9076182/5eccda93474f/c9ra09781c-f5.jpg

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