Rabkin David G, Whitehead Kevin J, Michaels Andrew D, Powell Douglas L, Karwande S V
Division of Cardiothoracic Surgery, Department of Surgery, University of Utah Medical Center, Salt Lake City, Utah, USA.
Clin Cardiol. 2009 Aug;32(8):E55-7. doi: 10.1002/clc.20427.
Systemic allergic reaction to a percutaneous patent foramen ovale (PFO) occlusion device is a rare event with only scattered reports in the literature. Serious allergic reactions to these devices have a poorly defined incidence, presentation, and natural history. We present a woman with a previously unknown nickel allergy who developed severe chest pain beginning the morning after percutaneous device closure of the PFO. Despite multiple visits to her cardiologists and primary care physicians, the cause of her chest pain remained unclear. After seeking a second opinion at our medical center, skin testing showed a severe reaction to nickel. These symptoms were refractory to treatment until device explantation 18 mo later. This case highlights the importance of recognizing nickel allergy as a cause of chest pain following implantation of certain types of devices used for closure of PFOs and other heart defects.
经皮卵圆孔未闭（PFO）封堵装置的全身性过敏反应是一种罕见事件，文献中仅有零星报道。这些装置引发的严重过敏反应，其发生率、表现及自然病程都尚不明确。我们报告一名女性，她此前未知对镍过敏，在经皮装置封堵PFO后的次日清晨开始出现严重胸痛。尽管多次就诊于心脏病专家和初级保健医生，其胸痛原因仍不明确。在我们医疗中心寻求二次诊断后，皮肤试验显示对镍有严重反应。这些症状在18个月后装置取出前一直难以治疗。该病例凸显了认识到镍过敏是植入用于封堵PFO及其他心脏缺陷的某些类型装置后胸痛原因的重要性。
