Motokura Ken, Tada Mizuki, Iwasawa Yasuhiro
Department of Chemistry, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
J Am Chem Soc. 2009 Jun 17;131(23):7944-5. doi: 10.1021/ja9012003.
Acidic montmorillonite-immobilized primary amines (H-mont-NH(2)) were found to be excellent acid-base bifunctional catalysts for one-pot reaction sequences, which are the first materials with coexisting acid and base sites active for acid-base tamdem reactions. For example, tandem deacetalization-Knoevenagel condensation proceeded successfully with the H-mont-NH(2), affording the corresponding condensation product in a quantitative yield. The acidity of the H-mont-NH(2) was strongly influenced by the preparation solvent, and the base-catalyzed reactions were enhanced by interlayer acid sites.
酸性蒙脱土负载的伯胺（H-蒙脱土-NH₂）被发现是用于一锅法反应序列的优异酸碱双功能催化剂，它们是首批具有共存酸碱位点且对酸碱串联反应有活性的材料。例如，H-蒙脱土-NH₂成功实现了串联脱缩醛化-Knoevenagel缩合反应，以定量产率得到了相应的缩合产物。H-蒙脱土-NH₂的酸度受制备溶剂的强烈影响，且层间酸位点增强了碱催化反应。
