• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于Knoevenagel缩合反应和1,3-偶极环加成多米诺反应的分子内接力催化策略

An intramolecular relay catalysis strategy for Knoevenagel condensation and 1,3-dipolar cycloaddition domino reactions.

作者信息

Yuan Xiaofeng, Wang Zijuan, Zhang Qiang, Luo Jun

机构信息

School of Chemical Engineering, Nanjing University of Science and Technology Nanjing 210094 China

Jiangsu Key Laboratory of Environmental Functional Materials, School of Chemistry, Biology and Material Engineering, Suzhou University of Science and Technology Suzhou 215009 China.

出版信息

RSC Adv. 2019 Jul 30;9(41):23614-23621. doi: 10.1039/c9ra04081a. eCollection 2019 Jul 29.

DOI:10.1039/c9ra04081a
PMID:35530586
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9073340/
Abstract

A relay catalysis strategy was established by using a bifunctional catalyst which was prepared by immobilization of organic chains containing secondary amine and Cu(ii) complex onto silica-coated nano-FeO. The simply prepared nanoparticles acted as efficient, intramolecular relays and magnetically recyclable base-metal bifunctional catalysts for Knoevenagel condensation and 1,3-dipolar cycloaddition domino reactions to prepare 5-substituted 1-tetrazoles with excellent yields.

摘要

通过将含有仲胺和铜（II）配合物的有机链固定在二氧化硅包覆的纳米FeO上制备双功能催化剂，从而建立了一种接力催化策略。这种简单制备的纳米颗粒作为高效的分子内接力体和可磁回收的贱金属双功能催化剂，用于Knoevenagel缩合反应和1,3-偶极环加成多米诺反应，以优异的产率制备5-取代-1-四唑。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/0cac4a322cfb/c9ra04081a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/17fde20d416e/c9ra04081a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/54b4c4c2f807/c9ra04081a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/df55a6006362/c9ra04081a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/e0aafca0c443/c9ra04081a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/eb385e089bf9/c9ra04081a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/849c73973487/c9ra04081a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/7008449bbddf/c9ra04081a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/0cac4a322cfb/c9ra04081a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/17fde20d416e/c9ra04081a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/54b4c4c2f807/c9ra04081a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/df55a6006362/c9ra04081a-s1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/e0aafca0c443/c9ra04081a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/eb385e089bf9/c9ra04081a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/849c73973487/c9ra04081a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/7008449bbddf/c9ra04081a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f461/9073340/0cac4a322cfb/c9ra04081a-f7.jpg

相似文献

1
An intramolecular relay catalysis strategy for Knoevenagel condensation and 1,3-dipolar cycloaddition domino reactions.用于Knoevenagel缩合反应和1,3-偶极环加成多米诺反应的分子内接力催化策略
RSC Adv. 2019 Jul 30;9(41):23614-23621. doi: 10.1039/c9ra04081a. eCollection 2019 Jul 29.
2
Cu(ii) immobilized on FeO@APTMS-DFX nanoparticles: an efficient catalyst for the synthesis of 5-substituted 1-tetrazoles with cytotoxic activity.负载于FeO@APTMS-DFX纳米颗粒上的Cu(ii)：一种用于合成具有细胞毒性活性的5-取代-1-四唑的高效催化剂。
Medchemcomm. 2017 Sep 15;8(10):1953-1964. doi: 10.1039/c7md00302a. eCollection 2017 Oct 1.
3
Efficient reduction of nitro compounds and domino preparation of 1-substituted-1-1,2,3,4-tetrazoles by Pd(ii)-polysalophen coated magnetite NPs as a robust versatile nanocomposite.通过钯（II）-聚水杨醛缩邻氨基酚包覆的磁铁矿纳米粒子作为一种强大的通用纳米复合材料，高效还原硝基化合物并多米诺式制备1-取代-1,2,3,4-四唑。
RSC Adv. 2021 Mar 30;11(21):12484-12499. doi: 10.1039/d1ra01164b. eCollection 2021 Mar 29.
4
Bifunctional Gyroidal MOFs: Highly Efficient Lewis Base and Lewis Acid Catalysts.双功能介观笼状金属有机骨架：高效路易斯碱和路易斯酸催化剂。
Chem Asian J. 2019 Oct 15;14(20):3682-3687. doi: 10.1002/asia.201900853. Epub 2019 Jul 30.
5
Amine-rich Nickel(II)-Xerogel as a Highly Active Bifunctional Metallo-organo Catalyst for Aqueous Knoevenagel Condensation and Solvent-free CO Cycloaddition.富含胺的镍（II）-干凝胶作为用于水相Knoevenagel缩合和无溶剂CO环加成反应的高活性双功能金属有机催化剂。
Inorg Chem. 2023 Sep 18;62(37):14959-14970. doi: 10.1021/acs.inorgchem.3c01669. Epub 2023 Sep 6.
6
Diphenylprolinol silyl ether catalysis in an asymmetric formal carbo [3 + 3] cycloaddition reaction via a domino Michael/Knoevenagel condensation.通过多米诺迈克尔/克诺文纳格尔缩合反应，二苯基脯氨醇硅醚催化不对称形式的碳[3 + 3]环加成反应。
Org Lett. 2009 Jan 1;11(1):45-8. doi: 10.1021/ol802330h.
7
A recyclable bifunctional acid-base organocatalyst with ionic liquid character. The role of site separation and spatial configuration on different condensation reactions.一种具有离子液体特性的可回收双功能酸碱有机催化剂。位阻分离和空间构型在不同缩合反应中的作用。
Phys Chem Chem Phys. 2011 Oct 14;13(38):17255-61. doi: 10.1039/c1cp21986c. Epub 2011 Aug 31.
8
Sulfonic acid-functionalized silica-coated magnetic nanoparticles as an efficient reusable catalyst for the synthesis of 1-substituted 1H-tetrazoles under solvent-free conditions.磺酸功能化二氧化硅包覆磁性纳米粒子作为一种高效可重复使用的催化剂，用于在无溶剂条件下合成1-取代-1H-四唑。
Dalton Trans. 2014 Sep 14;43(34):12967-73. doi: 10.1039/c4dt01664e.
9
Magnetically recoverable silica catalysed solvent-free domino Knoevenagel-hetero-Diels-Alder reaction to access divergent chromenones.磁性可回收硅胶催化无溶剂多米诺 Knoevenagel-杂-Diels-Alder 反应，以获得不同的色烯酮。
Org Biomol Chem. 2020 Mar 18;18(11):2058-2062. doi: 10.1039/d0ob00284d.
10
The synthesis of a bifunctional copper metal organic framework and its application in the aerobic oxidation/Knoevenagel condensation sequential reaction.双功能铜金属有机框架的合成及其在有氧氧化/克诺维纳格尔缩合连续反应中的应用。
Dalton Trans. 2016 Sep 21;45(35):13917-24. doi: 10.1039/c6dt01690a. Epub 2016 Aug 15.

引用本文的文献

1
Tetrazole derivatives synthesis green one-pot oxidation of benzyl alcohol using Cu(ii) immobilized on nanodiamond@folic acid catalyst.四唑衍生物的合成：使用固定在纳米金刚石@叶酸催化剂上的Cu(ii)对苯甲醇进行绿色一锅法氧化。
RSC Adv. 2025 Aug 28;15(37):30900-30914. doi: 10.1039/d5ra03496e. eCollection 2025 Aug 22.
2
Periodic mesoporous organosilica functionalized with -aminobenzenesulfonic acid: an efficient solid acid catalyst for one-pot synthesis of 5-substituted 1-tetrazoles under eco-friendly conditions.用对氨基苯磺酸功能化的周期性介孔有机硅：一种在环保条件下一锅法合成5-取代-1-四唑的高效固体酸催化剂。
Nanoscale Adv. 2025 May 19. doi: 10.1039/d5na00224a.
3

本文引用的文献

1
Cu(ii) immobilized on FeO@APTMS-DFX nanoparticles: an efficient catalyst for the synthesis of 5-substituted 1-tetrazoles with cytotoxic activity.负载于FeO@APTMS-DFX纳米颗粒上的Cu(ii)：一种用于合成具有细胞毒性活性的5-取代-1-四唑的高效催化剂。
Medchemcomm. 2017 Sep 15;8(10):1953-1964. doi: 10.1039/c7md00302a. eCollection 2017 Oct 1.
2
Bifunctional Solid Catalyst for Organic Reactions in Water: Simultaneous Anchoring of Acetylacetone Ligands and Amphiphilic Ionic Liquid "Tags" by Using a Dihydropyran Linker.用于水相有机反应的双功能固体催化剂：通过使用二氢吡喃链接剂同时锚定乙酰丙酮配体和两亲性离子液体“标签”。
Chem Asian J. 2018 Sep 4;13(17):2529-2542. doi: 10.1002/asia.201800567. Epub 2018 Aug 7.
3
Synthesis and Antimicrobial Activity of ()-1-Aryl-2-(1H-tetrazol-5-yl)acrylonitrile Derivatives via [3+2] Cycloaddition Reaction Using Reusable Heterogeneous Nanocatalyst under Microwave Irradiation.
通过微波辐射下使用可重复使用的多相纳米催化剂的[3 + 2]环加成反应合成（）-1-芳基-2-（1H-四唑-5-基）丙烯腈衍生物及其抗菌活性
Molecules. 2024 Sep 12;29(18):4339. doi: 10.3390/molecules29184339.
4
Nitrogen-Enriched Biguanidine-Functionalized Cobalt Ferrite Nanoparticles as a Heterogeneous Base Catalyst for Knoevenagel Condensation under Solvent-Free Conditions.富氮双胍功能化钴铁氧体纳米颗粒作为无溶剂条件下Knoevenagel缩合反应的多相碱催化剂
ACS Org Inorg Au. 2023 Jun 23;3(5):254-265. doi: 10.1021/acsorginorgau.3c00002. eCollection 2023 Oct 4.
5
Supramolecular Cu(ii) nanoparticles supported on a functionalized chitosan containing urea and thiourea bridges as a recoverable nanocatalyst for efficient synthesis of 1-tetrazoles.负载在含有尿素和硫脲桥的功能化壳聚糖上的超分子铜（II）纳米颗粒，作为一种可回收的纳米催化剂用于高效合成1-四氮唑。
RSC Adv. 2023 Sep 11;13(39):27088-27105. doi: 10.1039/d3ra01989f. eCollection 2023 Sep 8.
6
Design and characterization of an urea-bridged PMO supporting Cu(II) nanoparticles as highly efficient heterogeneous catalyst for synthesis of tetrazole derivatives.设计和表征一种尿素桥联的 PMO 支撑的 Cu(II)纳米粒子作为高效的非均相催化剂，用于合成四唑衍生物。
Sci Rep. 2022 Oct 28;12(1):18139. doi: 10.1038/s41598-022-22905-7.
7
Synthesis of (E)-2-(1H-tetrazole-5-yl)-3-phenylacrylenenitrile derivatives catalyzed by new ZnO nanoparticles embedded in a thermally stable magnetic periodic mesoporous organosilica under green conditions.在绿色条件下，新型 ZnO 纳米粒子嵌入在热稳定的磁性介孔有机硅中，用于催化（E）-2-（1H-四唑-5-基）-3-苯基丙烯腈衍生物的合成。
Sci Rep. 2022 Jun 24;12(1):10723. doi: 10.1038/s41598-022-13011-9.
8
Cysteic acid grafted to magnetic graphene oxide as a promising recoverable solid acid catalyst for the synthesis of diverse 4H-chromene.巯基乙酸接枝到磁性氧化石墨烯上作为一种有前途的可回收固体酸催化剂，用于合成多种 4H-色烯。
Sci Rep. 2020 Dec 1;10(1):20968. doi: 10.1038/s41598-020-77872-8.
A magnetic nanoparticle-supported N-heterocyclic carbene-palladacycle: an efficient and recyclable solid molecular catalyst for Suzuki-Miyaura cross-coupling of 9-chloroacridine.
磁性纳米粒子负载的N-杂环卡宾-钯环配合物：一种用于9-氯吖啶铃木-宫浦交叉偶联反应的高效可回收固体分子催化剂。
Chem Commun (Camb). 2017 Dec 5;53(97):13063-13066. doi: 10.1039/c7cc06958h.
4
Plasmolysis-Inspired Nanoengineering of Functional Yolk-Shell Microspheres with Magnetic Core and Mesoporous Silica Shell.基于质壁分离的仿生纳米工程技术制备具有磁性内核和介孔硅壳的功能性蛋黄壳微球。
J Am Chem Soc. 2017 Nov 1;139(43):15486-15493. doi: 10.1021/jacs.7b09055. Epub 2017 Oct 23.
5
Effect of Cu(II) ions on the enhancement of tetracycline adsorption by FeO@SiO-Chitosan/graphene oxide nanocomposite.Cu(II) 离子对 FeO@SiO-Chitosan/氧化石墨烯纳米复合材料增强四环素吸附性能的影响。
Carbohydr Polym. 2017 Feb 10;157:576-585. doi: 10.1016/j.carbpol.2016.10.025. Epub 2016 Oct 12.
6
An Efficient Passerini Tetrazole Reaction (PT-3CR).一种高效的Passerini四唑反应（PT-3CR）。
Green Chem. 2016;18(13):3718-3721. doi: 10.1039/C6GC00910G. Epub 2016 May 19.
7
The synthesis of a bifunctional copper metal organic framework and its application in the aerobic oxidation/Knoevenagel condensation sequential reaction.双功能铜金属有机框架的合成及其在有氧氧化/克诺维纳格尔缩合连续反应中的应用。
Dalton Trans. 2016 Sep 21;45(35):13917-24. doi: 10.1039/c6dt01690a. Epub 2016 Aug 15.
8
Uncovering the Role of Metal Catalysis in Tetrazole Formation by an In Situ Cycloaddition Reaction: An Experimental Approach.揭示金属催化在原位环加成反应中形成四唑的作用：一种实验方法。
Angew Chem Int Ed Engl. 2015 Sep 28;54(40):11795-9. doi: 10.1002/anie.201505118. Epub 2015 Aug 18.
9
A trifunctional mesoporous silica-based, highly active catalyst for one-pot, three-step cascade reactions.一种用于一锅三步串联反应的三功能介孔二氧化硅基高活性催化剂。
Chem Commun (Camb). 2015 May 18;51(40):8496-9. doi: 10.1039/c5cc01694k.
10
Selective functionalization of hollow nanospheres with Acid and base groups for cascade reactions.用于级联反应的带有酸基和碱基的中空纳米球的选择性功能化
Chemistry. 2015 May 11;21(20):7403-7. doi: 10.1002/chem.201500532. Epub 2015 Mar 27.