Second-generation histamine H(2)-receptor antagonists with gastric mucosal defensive properties.

Unlike the earlier agents in this class, certain of the newer histamine H(2)-receptor antagonists (so-called second-generation HB(2B)-receptor antagonists) have recently been reported to promote gastric mucosal defenses. We review herein the structure, specificity, and mechanisms of these agents with a special focus on their cytoprotective/gastroprotective actions.