大鼠胃内分泌细胞中组胺释放的H2受体介导的反馈调节证据。
Evidence for H2-receptor-mediated feed-back regulation of histamine release from endocrine cells in the rat stomach.
作者信息
Håkanson R, Larsson L I, Liedberg G, Sundler F
出版信息
J Physiol. 1978 Mar;276:151-7. doi: 10.1113/jphysiol.1978.sp012224.
Abstract
- Pentagastrin reduces the concentration of gastric mucosal histamine in the rat. This effect is counteracted by large doses of histamine H2-receptor agonists which are particularly effective if infused I.V. 2. After blockade of histamine H2-receptors but not of H1-receptors, the pentagastrin-induced reduction of mucosal histamine is greatly augmented and H2-receptor agonists no longer inhibit the response to pentagastrin. 3. It is suggested that in the rat stomach, H2-receptors occur on the histamine storing endocrine cells as well as on parietal cells and that mobilized mucosal histamine inhibits further release of histamine by way of H2-receptor-mediated auto feed-back.
摘要
- 五肽胃泌素可降低大鼠胃黏膜组胺浓度。大剂量组胺H2受体激动剂可抵消这一作用，静脉输注时尤为有效。2. 在组胺H2受体被阻断而H1受体未被阻断后，五肽胃泌素诱导的黏膜组胺减少作用显著增强，且H2受体激动剂不再抑制对五肽胃泌素的反应。3. 提示在大鼠胃中，H2受体存在于储存组胺的内分泌细胞以及壁细胞上，动员的黏膜组胺通过H2受体介导的自身反馈抑制组胺的进一步释放。
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本文引用的文献
1
MOBILIZATION AND FORMATION OF HISTAMINE IN THE GASTRIC MUCOSA AS RELATED TO ACID SECRETION.胃黏膜中组胺的动员与形成及其与胃酸分泌的关系
J Physiol. 1964 Nov;174(3):400-16. doi: 10.1113/jphysiol.1964.sp007494.
2
The formation of histamine by fetal rat liver.胎鼠肝脏中组胺的形成。
Biochem Pharmacol. 1962 Apr-May;11:315-22. doi: 10.1016/0006-2952(62)90054-0.
3
Localization of cells containing and forming histamine in the gastric mucosa of the rat.大鼠胃黏膜中含组胺及形成组胺的细胞的定位
Exp Cell Res. 1967 Aug;47(1):108-15. doi: 10.1016/0014-4827(67)90214-5.
4
The role of endogenous gastrin in the activation of gastric histidine decarboxylase in the rat. Effect of antrectomy and vagal denervation.内源性胃泌素在大鼠胃组氨酸脱羧酶激活中的作用。胃窦切除术和迷走神经切断术的影响。
Eur J Pharmacol. 1970 Sep 1;12(1):94-103. doi: 10.1016/0014-2999(70)90033-6.
5
Improved fluorometric assay of histamine: condensation with O-phthalaldehyde at -20 degrees C.组胺荧光测定法的改进：在-20℃下与邻苯二甲醛缩合。
Anal Biochem. 1974 Aug;60(2):560-7. doi: 10.1016/0003-2697(74)90267-x.
6
Correlation between serum gastrin concentration and rat stomach histidine decarboxylase activity.血清胃泌素浓度与大鼠胃组织组氨酸脱羧酶活性之间的相关性。
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7
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