大鼠胃内分泌细胞中组胺释放的H2受体介导的反馈调节证据。

Håkanson R, Larsson L I, Liedberg G, Sundler F

J Physiol. 1978 Mar;276:151-7. doi: 10.1113/jphysiol.1978.sp012224.

Pentagastrin reduces the concentration of gastric mucosal histamine in the rat. This effect is counteracted by large doses of histamine H2-receptor agonists which are particularly effective if infused I.V. 2. After blockade of histamine H2-receptors but not of H1-receptors, the pentagastrin-induced reduction of mucosal histamine is greatly augmented and H2-receptor agonists no longer inhibit the response to pentagastrin. 3. It is suggested that in the rat stomach, H2-receptors occur on the histamine storing endocrine cells as well as on parietal cells and that mobilized mucosal histamine inhibits further release of histamine by way of H2-receptor-mediated auto feed-back.

五肽胃泌素可降低大鼠胃黏膜组胺浓度。大剂量组胺H2受体激动剂可抵消这一作用，静脉输注时尤为有效。2. 在组胺H2受体被阻断而H1受体未被阻断后，五肽胃泌素诱导的黏膜组胺减少作用显著增强，且H2受体激动剂不再抑制对五肽胃泌素的反应。3. 提示在大鼠胃中，H2受体存在于储存组胺的内分泌细胞以及壁细胞上，动员的黏膜组胺通过H2受体介导的自身反馈抑制组胺的进一步释放。

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

Håkanson R, Larsson L I, Liedberg G, Sundler F

J Physiol. 1978 Mar;276:151-7. doi: 10.1113/jphysiol.1978.sp012224.

Pentagastrin reduces the concentration of gastric mucosal histamine in the rat. This effect is counteracted by large doses of histamine H2-receptor agonists which are particularly effective if infused I.V. 2. After blockade of histamine H2-receptors but not of H1-receptors, the pentagastrin-induced reduction of mucosal histamine is greatly augmented and H2-receptor agonists no longer inhibit the response to pentagastrin. 3. It is suggested that in the rat stomach, H2-receptors occur on the histamine storing endocrine cells as well as on parietal cells and that mobilized mucosal histamine inhibits further release of histamine by way of H2-receptor-mediated auto feed-back.

五肽胃泌素可降低大鼠胃黏膜组胺浓度。大剂量组胺H2受体激动剂可抵消这一作用，静脉输注时尤为有效。2. 在组胺H2受体被阻断而H1受体未被阻断后，五肽胃泌素诱导的黏膜组胺减少作用显著增强，且H2受体激动剂不再抑制对五肽胃泌素的反应。3. 提示在大鼠胃中，H2受体存在于储存组胺的内分泌细胞以及壁细胞上，动员的黏膜组胺通过H2受体介导的自身反馈抑制组胺的进一步释放。