Wijsman D J, Hekster Y A, Keyser A, Renier W O, Meinardi H
Institute of Neurology, University Hospital Nijmegen, The Netherlands.
Pharm Weekbl Sci. 1991 Aug 23;13(4):182-8. doi: 10.1007/BF01957744.
In order to study the practicability of rating scales in the regular care of people with epilepsy, indices have been developed and tested on their validity. These indices consist of the Index of Seizures, representing seizure activity, and the Composite Index of Impairment concerning the severity of impairment caused by the seizure type and frequency and the side-effects of anti-epileptic drug treatment. The indices have been applied in a retrospective quantitative evaluation of anti-epileptic drug therapy. The medical records of 250 randomly selected patients registered at an adult out-patient clinic have been reviewed. Their seizures have been classified as generalized tonic-clonic, simple partial and/or complex partial. The distribution of this population according to these indices has been studied, which leads us to the following conclusions: the global indices are valid for clinical application; in 18.6% of the patients studied there was severe impairment and unacceptable seizure control; combined types of seizure are difficult to control; no significant difference is demonstrated between monotherapy and polytherapy regarding the amount of neurotoxicity. The indices can be determined rapidly and therefore may become valuable aids for the physician in an out-patient clinic to support a decision whether or not to revise current anti-epileptic drug therapy.
为研究评定量表在癫痫患者常规护理中的实用性，已开发出相关指标并对其有效性进行了测试。这些指标包括代表癫痫发作活动的癫痫发作指数，以及涉及癫痫发作类型、频率及抗癫痫药物治疗副作用所导致损害严重程度的综合损害指数。这些指标已应用于抗癫痫药物治疗的回顾性定量评估。对在一家成人门诊随机选取的250例患者的病历进行了审查。他们的癫痫发作被分类为全身性强直阵挛发作、单纯部分性发作和/或复杂部分性发作。根据这些指标对该人群的分布情况进行了研究，由此得出以下结论：整体指标在临床应用中是有效的；在所研究的患者中，18.6%存在严重损害且癫痫发作控制不佳；联合发作类型难以控制；单药治疗和多药治疗在神经毒性程度方面未显示出显著差异。这些指标能够快速确定，因此可能成为门诊医生决定是否调整当前抗癫痫药物治疗的有价值辅助工具。
