Rwiza H T, Keyser A, Hekster Y A, Pool M, Verwey H
Institute of Neurology, Sint Radboud Hospital, Nijmegen, the Netherlands.
Pharm Weekbl Sci. 1989 Apr 28;11(2):50-5. doi: 10.1007/BF01962975.
An epidemiological analysis was performed of the adult, out-patient epilepsy clinic population of a university hospital during the period from 1 January 1981 through 30 June 1985. The number of patients that could be traced amounted to 590. An at random sample of 207 were retrospectively analysed. Gender distribution was male:female = 1.46. The mean age was 37.4 years. The diagnoses were classified according to the classification of the International League Against Epilepsy (ILAE). A preponderance of partial seizures was present, reflecting the selection in a university out-patient clinic of more difficult to treat forms of epilepsy. Antiepileptic drugs used in the treatment varied; monotherapy was obtained in 46% of the cases and carbamazepine was the most frequently prescribed drug (49%). Changes in seizure severity and factors associated with epilepsy are described. A discrepancy was found between the suspected drug levels, based upon the physician's judgement, and the plasma level measured in those patients in whom drug levels were monitored; factors interfering with clinical judgement are discussed.
对一所大学医院1981年1月1日至1985年6月30日期间成人门诊癫痫诊所的患者群体进行了流行病学分析。可追踪到的患者数量为590例。对随机抽取的207例患者进行了回顾性分析。性别分布为男性：女性 = 1.46。平均年龄为37.4岁。诊断根据国际抗癫痫联盟（ILAE）的分类进行。部分性发作占优势，这反映了大学门诊诊所中选择了更难治疗的癫痫形式。治疗中使用的抗癫痫药物各不相同；46%的病例采用单药治疗，卡马西平是最常处方的药物（49%）。描述了癫痫发作严重程度的变化以及与癫痫相关的因素。在根据医生判断怀疑的药物水平与监测药物水平的患者中测量的血浆水平之间发现了差异；讨论了干扰临床判断的因素。
