Beraneck M, Lambert F M
Laboratoire de Neurobiologie des Réseaux Sensorimoteurs, Centre National de la Recherche Scientifique Unité Mixte de Recherche 7060, Université Paris Descartes, 45 rue des Saints-Pères, 75270 Paris, Cédex 06, France.
J Neurophysiol. 2009 Jul;102(1):12-4. doi: 10.1152/jn.00351.2009. Epub 2009 May 20.
Many mutant mouse strains display pathological behaviors, such as head tilts, head bobbing, or circling and waltzing, strongly suggesting that their vestibular system is impaired. Recently, Yoder and Taube studied head direction signals in tilted mutant mice, which have an impaired gravitation sensitivity in the vestibular periphery. Here we summarize their findings and discuss a caveat related to the general use of mutant mouse strains in systems physiology.
许多突变小鼠品系表现出病理行为，如头部倾斜、点头或转圈及跳跃，这强烈表明它们的前庭系统受损。最近，约德和陶布研究了倾斜突变小鼠的头部方向信号，这些小鼠在前庭外周的重力敏感性受损。在此，我们总结他们的发现，并讨论在系统生理学中普遍使用突变小鼠品系相关的一个注意事项。
