Sarvananthan Nagini, Surendran Mylvaganam, Roberts Eryl O, Jain Sunila, Thomas Shery, Shah Nitant, Proudlock Frank A, Thompson John R, McLean Rebecca J, Degg Christopher, Woodruff Geoffrey, Gottlob Irene
Department of Ophthalmology, University of Leicester and Leicester Royal Infirmary, Leicester, United Kingdom.
Invest Ophthalmol Vis Sci. 2009 Nov;50(11):5201-6. doi: 10.1167/iovs.09-3486. Epub 2009 May 20.
Nystagmus, which can be infantile (congenital) or acquired, affects all ages. The prevalence of nystagmus in the general population is unknown. New genetic research and therapeutic modalities are emerging. Previous estimates have been based on wider ophthalmic epidemiologic studies within specific occupational or age groups. The authors carried out the first epidemiologic study to specifically establish the prevalence of nystagmus in Leicestershire and Rutland in the United Kingdom.
Three independent data sources identified persons with nystagmus from the hospital and community. The first was a hospital-based questionnaire and clinical survey (n = 238). The visually impaired services (n = 414) and education services (n = 193) in Leicestershire provided the second and third separately obtained community-based sources of information. Capture-recapture statistical analysis was used to estimate prevalence.
The prevalence of nystagmus in the general population was estimated to be 24.0 per 10,000 population (95% confidence interval [CI], +/-5.3). The most common forms of nystagmus were neurologic nystagmus (6.8 per 10,000 population; 95% CI, +/-4.6), nystagmus associated with low vision such as congenital cataracts (4.2 per 10,000; 95% CI, +/-1.2), and nystagmus associated with retinal diseases such as achromatopsia (3.4 per 10,000 population; 95% CI, +/-2.1). Within ethnic groups, nystagmus was significantly more common in the white European population than in the Asian (Indian, Pakistani, other Asian backgrounds) population (P = 0.004).
The findings suggest that nystagmus is more common in the general population than previously thought. This may be of significance in resource allocation and health care planning.
眼球震颤可分为婴儿型（先天性）或后天性，影响所有年龄段。一般人群中眼球震颤的患病率尚不清楚。新的基因研究和治疗方法不断涌现。以往的估计是基于特定职业或年龄组内更广泛的眼科流行病学研究。作者开展了第一项流行病学研究，专门确定英国莱斯特郡和拉特兰郡眼球震颤的患病率。
三个独立的数据来源从医院和社区中识别出患有眼球震颤的人。第一个是基于医院的问卷调查和临床调查（n = 238）。莱斯特郡的视力障碍服务机构（n = 414）和教育服务机构（n = 193）分别提供了第二个和第三个独立获得的社区信息来源。采用捕获-再捕获统计分析来估计患病率。
估计一般人群中眼球震颤的患病率为每10000人中有24.0例（95%置信区间[CI]，±5.3）。最常见的眼球震颤类型是神经性眼球震颤（每10000人中有6.8例；95% CI，±4.6）、与低视力相关的眼球震颤，如先天性白内障（每10000人中有4.2例；95% CI，±1.2），以及与视网膜疾病相关的眼球震颤，如全色盲（每10000人中有3.4例；95% CI，±2.1）。在不同种族群体中，欧洲白人人口中的眼球震颤明显比亚洲（印度、巴基斯坦、其他亚洲背景）人口中更常见（P = 0.004）。
研究结果表明，眼球震颤在一般人群中比以前认为的更常见。这可能对资源分配和医疗保健规划具有重要意义。
