University of Leicester Ulverscroft Eye Unit, School of Psychology and Vision Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Building, Leicester Royal Infirmary, Leicester, United Kingdom.
Medical Physics and Clinical Engineering, Nottingham University Hospitals NHS Trust, United Kingdom.
Invest Ophthalmol Vis Sci. 2024 Apr 1;65(4):11. doi: 10.1167/iovs.65.4.11.
Our primary aim was to compare adult full-field ERG (ffERG) responses in albinism, idiopathic infantile nystagmus (IIN), and controls. A secondary aim was to investigate the effect of within-subject changes in nystagmus eye movements on ffERG responses.
Dilated Ganzfeld flash ffERG responses were recorded using DTL electrodes under conditions of dark (standard and dim flash) and light adaptation in 68 participants with albinism, 43 with IIN, and 24 controls. For the primary aim, the effect of group and age on ffERG responses was investigated. For the secondary aim, null region characteristics were determined using eye movements recorded prior to ffERG recordings. ffERG responses were recorded near and away from the null regions of 18 participants also measuring the success rate of recordings.
For the primary aim, age-adjusted photopic a- and b-wave amplitudes were consistently smaller in IIN compared with controls (P < 0.0001), with responses in both groups decreasing with age. In contrast, photopic a-wave amplitudes increased with age in albinism (P = 0.0035). For the secondary aim, more intense nystagmus significantly reduced the success rate of measurable responses. Within-subject changes in nystagmus intensity generated small, borderline significant differences in photopic b-wave peak times and a-and b-wave amplitudes under scotopic conditions with standard flash.
Age-adjusted photopic ffERG responses are significantly reduced in IIN adding to the growing body of evidence of retinal abnormalities in IIN. Differences between photopic responses in albinism and controls depend on age. Success at obtaining ffERG responses could be improved by recording responses at the null region.
我们的主要目的是比较白化病、特发性婴儿性眼球震颤（IIN）和对照组成人全视野视网膜电图（ffERG）反应。次要目的是研究眼球震颤眼动对内眼全视野视网膜电图反应的影响。
在暗（标准和弱闪光）和明适应条件下，使用 DTL 电极记录 68 例白化病患者、43 例 IIN 患者和 24 例对照组患者的扩瞳全视野闪光 ffERG 反应。为了达到主要目的，我们研究了组间和年龄对 ffERG 反应的影响。为了达到次要目的，我们使用在 ffERG 记录之前记录的眼动来确定空区特征。我们还对 18 名参与者进行了记录，记录了他们靠近和远离空区的 ffERG 反应，以及记录的成功率。
为了达到主要目的，调整年龄后的 IIN 明适应 a-和 b-波振幅明显小于对照组（P < 0.0001），两组的反应都随年龄的增加而降低。相比之下，白化病患者的明适应 a-波振幅随年龄增加而增加（P = 0.0035）。为了达到次要目的，更强烈的眼球震颤显著降低了可测量反应的成功率。在弱闪光标准条件下，内眼震颤强度的个体内变化导致明适应 b-波峰值时间和 a-和 b-波振幅的小的、边缘显著差异。
IIN 患者的明适应 ffERG 反应明显降低，这增加了 IIN 视网膜异常的证据。白化病和对照组的明适应反应之间的差异取决于年龄。在空区记录反应可以提高 ffERG 反应的成功率。
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