锁核酸作为一类新型治疗剂。

Locked nucleic acid as a novel class of therapeutic agents.

作者信息

Veedu Rakesh N, Wengel Jesper

机构信息

Nucleic Acid Center, Department of Physics and Chemistry, University of Southern Denmark, Odense, Denmark.

出版信息

RNA Biol. 2009 Jul-Aug;6(3):321-3. doi: 10.4161/rna.6.3.8807. Epub 2009 Jul 18.

DOI:10.4161/rna.6.3.8807

PMID:19458498

Abstract

Locked Nucleic Acid (LNA) is a nucleic acid analogue with unprecedented binding affinity and excellent specificity toward complementary RNA and DNA oligonucleotides. The remarkable properties of LNA have led to applications within various gene silencing strategies both in vitro and in vivo. In the present review, we highlight the uses of LNA for regulation of gene expression with emphasis on RNA targeting.

摘要

锁核酸（LNA）是一种核酸类似物，对互补RNA和DNA寡核苷酸具有前所未有的结合亲和力和出色的特异性。LNA的卓越特性已使其在体外和体内的各种基因沉默策略中得到应用。在本综述中，我们重点介绍LNA在基因表达调控中的应用，尤其侧重于RNA靶向。