Salihovic Admir, Taladriz-Sender Andrea, Burley Glenn A
Department of Pure & Applied Chemistry, University of Strathclyde 295 Cathedral Street Glasgow G1 1XL UK
Strathclyde Centre for Molecular Bioscience, University of Strathclyde UK.
Chem Sci. 2025 Jun 5. doi: 10.1039/d5sc03026a.
Nucleoside analogues are used throughout nature. They comprise the key building blocks in nucleic acids and in second messenger small molecules. Additionally, modifications to the sugar and nucleobase moieties have been a pervasive feature in the development of nucleoside therapeutics. Despite their ubiquity across all facets of medicinal chemistry and biology, methods to prepare nucleoside analogues are challenging. Recent innovations in the chemical and biocatalytic syntheses of nucleosides offer new opportunities for the step-efficient and environmentally sustainable preparation of these high value analogues. This perspective outlines the key innovations between 2020-2025 and presents opportunities for further integration of these strategies to prepare nucleoside analogues not possible using each of these approaches in isolation.
核苷类似物在自然界中广泛存在。它们是核酸和第二信使小分子中的关键组成部分。此外，对糖和核苷酸碱基部分的修饰一直是核苷治疗药物开发中的一个普遍特征。尽管它们在药物化学和生物学的各个方面都很普遍，但制备核苷类似物的方法仍具有挑战性。核苷化学合成和生物催化合成方面的最新创新为高效且环境可持续地制备这些高价值类似物提供了新机会。本综述概述了2020年至2025年间的关键创新，并提出了进一步整合这些策略的机会，以制备单独使用每种方法都无法实现的核苷类似物。
