Raj Ashok, Kailasnath Vasundhara P, Bertolone Salvatore, McFarland Janice G
Division of Hematology Oncology and Bone Marrow Transplantation, Department of Pediatrics, University of Louisville, Louisville, Kentucky, USA.
Pediatr Blood Cancer. 2009 Sep;53(3):459-61. doi: 10.1002/pbc.21997.
Neonatal alloimmune thrombocytopenia (NAIT) is one of the most frequent causes of both severe thrombocytopenia and intracranial hemorrhage (ICH) in fetuses and term neonates. The diagnosis is established by demonstrating antibodies against human platelet antigens (HPA) and discordance in platelet antigen typing between parents or between the mother and neonate. We report a case of NAIT that was likely due to maternal sensitization to HPA-9b (Max(a)), a recently recognized, rare platelet-specific antigen.
新生儿同种免疫性血小板减少症（NAIT）是胎儿和足月儿严重血小板减少症及颅内出血（ICH）最常见的病因之一。通过检测针对人类血小板抗原（HPA）的抗体以及父母之间或母亲与新生儿之间血小板抗原分型不一致来确诊。我们报告一例NAIT病例，可能是由于母亲对HPA-9b（Max(a)）致敏所致，HPA-9b是一种最近才被认识的罕见血小板特异性抗原。
