Moncharmont P, Courvoisier S, Pagnier A, Cotta L, Debillon T, Rigal D
French Blood Establishment, Rhône-Alpes Lyon Department, Lyon, France.
Acta Paediatr. 2007 Nov;96(11):1701-3. doi: 10.1111/j.1651-2227.2007.00483.x. Epub 2007 Sep 10.
The HPA-15 platelet (PLT) group was recently described. Severe neonatal thrombocytopenia due to alloimmunization by HPA-15b has very rarely been observed. A 22-year-old mother, gravida 1/para 1, gave birth to a male infant who presented with a severe thrombocytopenia, the PLT count recorded to be 3 x10(9)/L. A few hours after birth, he developed purpura with extensive haematomas but without visceral or intracranial haemorrhage (ICH). Two PLT transfusions were given including one using maternal PLTs. The infant's PLT count was 267 x 10(9)/L on day 6. The maternal platelet group was HPA-15a/a and her infant was HPA-15a/b. Anti-HPA-15b antibodies was found in maternal serum.
HPA-15b maternal alloimmunization may induce severe neonatal thrombocytopenia. In order to establish the frequency of neonatal alloimmune thrombocytopenia (NAIT) due to anti-HPA-15b antibodies, an improved detection method is necessary.
最近描述了HPA - 15血小板（PLT）组。由HPA - 15b同种免疫引起的严重新生儿血小板减少症非常罕见。一名22岁初产妇，孕1产1，产下一名男婴，该男婴出现严重血小板减少症，血小板计数记录为3×10⁹/L。出生后数小时，他出现紫癜并伴有广泛血肿，但无内脏或颅内出血（ICH）。进行了两次血小板输注，其中一次使用母亲的血小板。婴儿在第6天的血小板计数为267×10⁹/L。母亲的血小板组为HPA - 15a/a，其婴儿为HPA - 15a/b。在母亲血清中发现了抗HPA - 15b抗体。
HPA - 15b母亲同种免疫可能诱发严重新生儿血小板减少症。为了确定由抗HPA - 15b抗体引起的新生儿同种免疫性血小板减少症（NAIT）的发生率，需要改进检测方法。
