Xiao Shu-hua, Xue Jian, Wu Zhong-xin
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO Collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2009 Feb 28;27(1):65-9.
Currently praziquantel is one of the major drugs used in treatment of schistosomiasis and other trematode infections. Recent experimental studies indicate that a new anthelmintic, tribendimidine, is used in the treatment of intestinal nematodes, also possesses effect against several species of trematodes including Clonorchis sinensis, Opisthorchis viverrini and Echinostoma caproni. Tribendimidine is even more effective against C. sinensis in rats that a single 300 mg/kg oral dose cures almost all of the animals treated, a lower cure dose than praziquantel (375-500 mg/kg). The anti-malarial drugs artemether and artesunate are not only effective in the prevention of schistosomiasis, but also effective against several species of trematodes, especially C. sinensis. The single oral dose of both drugs to cure or achieve high efficacy in infected rats is 75 mg/kg. This review summarized research progress on tribendimidine, artesunate, and artemether in experimental animals infected with C. sinensis and other species of trematodes.
目前，吡喹酮是治疗血吸虫病和其他吸虫感染的主要药物之一。最近的实验研究表明，一种新的驱虫药三苯双脒，用于治疗肠道线虫，对包括华支睾吸虫、麝猫后睾吸虫和卡氏棘口吸虫在内的几种吸虫也有作用。三苯双脒对大鼠体内的华支睾吸虫更有效，单次口服剂量300mg/kg几乎能治愈所有接受治疗的动物，这一比吡喹酮（375 - 500mg/kg）更低的治愈剂量。抗疟药物蒿甲醚和青蒿琥酯不仅对血吸虫病的预防有效，对几种吸虫尤其是华支睾吸虫也有效。两种药物在感染大鼠中单次口服治愈或达到高效的剂量均为75mg/kg。本综述总结了三苯双脒、青蒿琥酯和蒿甲醚在感染华支睾吸虫和其他吸虫的实验动物中的研究进展。
