一种优先结合乙酰胆碱、埃博霉素和尼古丁的水溶性三亚苯。
A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine.
作者信息
Givelet Cécile, Buffeteau Thierry, Arnaud-Neu Françoise, Hubscher-Bruder Véronique, Bibal Brigitte
机构信息
Université de Bordeaux, Institut des Sciences Moléculaires,CNRS UMR 5255, 351 cours de la Libération, 33405 Talence, France.
出版信息
J Org Chem. 2009 Jul 17;74(14):5059-62. doi: 10.1021/jo900683x.
PMID:19459648
Abstract
Synthesis and binding properties of a new hydrosoluble triphenylene 1b are reported. Selective recognition of acetylcholine (ACh) against other aliphatic ammoniums is achieved by this flat receptor, which also forms complexes with epibatidine and nicotine. Ionic pairing and hydrophobic effects between host 1b and ACh are studied by infrared spectroscopy.
摘要
报道了一种新型水溶性三亚苯1b的合成及结合性质。这种平面受体实现了对乙酰胆碱（ACh）相对于其他脂肪族铵类的选择性识别，它还能与埃博霉素和尼古丁形成复合物。通过红外光谱研究了主体1b与ACh之间的离子配对和疏水作用。
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