A hydrosoluble triphenylene that preferentially binds acetylcholine, epibatidine, and nicotine.
作者信息
Givelet Cécile, Buffeteau Thierry, Arnaud-Neu Françoise, Hubscher-Bruder Véronique, Bibal Brigitte
机构信息
Université de Bordeaux, Institut des Sciences Moléculaires,CNRS UMR 5255, 351 cours de la Libération, 33405 Talence, France.
出版信息
J Org Chem. 2009 Jul 17;74(14):5059-62. doi: 10.1021/jo900683x.
PMID:19459648
Abstract
Synthesis and binding properties of a new hydrosoluble triphenylene 1b are reported. Selective recognition of acetylcholine (ACh) against other aliphatic ammoniums is achieved by this flat receptor, which also forms complexes with epibatidine and nicotine. Ionic pairing and hydrophobic effects between host 1b and ACh are studied by infrared spectroscopy.
摘要
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