Glutest Neo Super新型手持式血糖仪可校正血细胞比容调整样本及贫血患者样本中血细胞比容值的影响。

Glutest Neo Super--a new handheld blood glucose meter-corrects for the effects of the hematocrit values in both hematocrit-adjusted samples and samples obtained from anemic patients.

作者信息

Yakushiji Fumiatsu, Fujita Hiroshi, Suzuki Hiroshi, Joukyu Ritsuko, Yasuda Mutsuko, Terayama Yoshiyasu, Nagasawa Kaoru, Ohwada Akira, Taniguchi Ken, Fujiki Kazuhiko, Shimojo Masako, Kinoshita Hiroyuki

机构信息

Department of Internal Medicine, Toranomon Hospital, Tokyo, Japan.

出版信息

Diabetes Technol Ther. 2009 Jun;11(6):369-72. doi: 10.1089/dia.2008.0095.

DOI:10.1089/dia.2008.0095

PMID:19459765

Abstract

BACKGROUND

Handheld blood glucose (BG) meters are convenient tools that are widely used to measure the BG levels. However, the hematocrit (Hct) value has been identified as a confounding factor for accurate BG measurement. Some BG meters are equipped with an Hct-correcting feature, whose effectiveness has been tested previously. Nevertheless, the measurements yielded by many BG meters are confounded by the Hct values. Recently, a new BG meter equipped with an Hct-correcting feature has been developed; however, its effectiveness has not yet been confirmed.

STUDY DESIGN

Venous blood samples were collected from two healthy volunteers, and the Hct values in the samples were adjusted to approximately 0%, 10%, 20%, 30%, 40%, 50%, and 60%. Further, venous blood samples were collected from 10 anemic patients (Hct <40%). The whole BG (WBG) levels in the samples were measured using two devices-the new BG meter (Glutest Neo Super [Sanwa Kagaku Kenkyusho Co. Ltd., Nagoya, Japan]) and a standard BG meter (OneTouch Ultra [Life Scan Inc., Milpitas, CA]). For reference, plasma glucose (PG) levels were measured using a machine at our hospital laboratory (GA08 [A&T Co., Kanagawa, Japan]). The bias in the measurements was calculated as follows: bias = ([WBG - PG]/PG) x 100. Further, the correlation between the Hct values and the bias was assessed by performing linear regression analysis.

RESULTS

In both the Hct-adjusted samples and the samples obtained from anemic patients, the WBG levels measured using Glutest Neo Super were minimally affected by the Hct values, while those measured using OneTouch Ultra were affected by the Hct values to a statistically significant extent.

CONCLUSIONS

The Hct-correcting feature of the new BG meter Glutest Neo Super was effective. The use of this new device for BG measurements may lead to more appropriate treatment selection.

摘要

背景

手持式血糖仪是广泛用于测量血糖水平的便捷工具。然而，血细胞比容（Hct）值已被确定为准确测量血糖的一个混杂因素。一些血糖仪配备了Hct校正功能，其有效性此前已得到测试。尽管如此，许多血糖仪的测量结果仍受Hct值的干扰。最近，一种配备Hct校正功能的新型血糖仪已被开发出来；然而，其有效性尚未得到证实。

研究设计

从两名健康志愿者采集静脉血样本，并将样本中的Hct值调整至约0%、10%、20%、30%、40%、50%和60%。此外，从10名贫血患者（Hct<40%）采集静脉血样本。使用两种设备——新型血糖仪（Glutest Neo Super[日本名古屋三和化学研究所]）和标准血糖仪（OneTouch Ultra[美国加利福尼亚州米尔皮塔斯生命扫描公司]）测量样本中的全血糖（WBG）水平。作为对照，使用我院实验室的一台仪器（GA08[日本神奈川县A&T公司]）测量血浆葡萄糖（PG）水平。测量偏差按以下公式计算：偏差=（[WBG - PG]/PG）×100。此外，通过进行线性回归分析评估Hct值与偏差之间的相关性。