Nagata Tomoyuki, Ishii Kazuhiro, Ito Tatsuhiko, Aoki Kimiyoshi, Ehara Yoshito, Kada Hirohide, Furukawa Haruko, Tsumura Maki, Shinagawa Shunichiro, Kasahara Hiroo, Nakayama Kazuhiko
Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Kashiwa, Chiba, Japan.
Psychiatry Clin Neurosci. 2009 Aug;63(4):449-54. doi: 10.1111/j.1440-1819.2009.01968.x. Epub 2009 Apr 29.
The purpose of the present study was to investigate the relationship between delusional thoughts (delusional ideation or misidentification) and frontal lobe function using the Japanese version of the Frontal Assessment Battery (FAB) bedside screening neuropsychological test in early stage Alzheimer's disease (AD) patients.
Forty-eight probable AD patients with Mini-Mental State Examination score >or=18 points and a clinical dementia rating score of either 0.5 or 1.0 were divided into two groups based on data obtained from interviews with their caregivers: a delusional thought group (n = 19) and a non-delusional thought group (n = 29). The FAB total and subtest scores were then compared for the two groups.
Significant differences were found between the FAB total (P < 0.01) and subtest scores (similarities, motor series, conflicting instructions; P < 0.05) for the two groups. Multiple regression analysis showed that delusional thought was significantly associated with the FAB total score.
In addition to episodic memory disorders, a reduction in the FAB score may reflect frontal lobe dysfunctions, including executive function, in patients with AD, leading to delusional ideation.
本研究旨在使用日本版简易精神状态检查表（FAB）床边筛查神经心理测试，调查早期阿尔茨海默病（AD）患者的妄想思维（妄想观念或错误识别）与额叶功能之间的关系。
将48名简易精神状态检查表评分≥18分且临床痴呆评定量表评分为0.5或1.0的疑似AD患者，根据从其照顾者访谈中获得的数据分为两组：妄想思维组（n = 19）和非妄想思维组（n = 29）。然后比较两组的FAB总分及各子测试分数。
两组在FAB总分（P < 0.01）及子测试分数（相似性、运动系列、冲突指令；P < 0.05）方面存在显著差异。多元回归分析表明，妄想思维与FAB总分显著相关。
除了情景记忆障碍外，FAB评分降低可能反映AD患者存在包括执行功能在内的额叶功能障碍，从而导致妄想观念。
Zotero 插件