Nakaaki Shutaro, Murata Yoshie, Sato Junko, Shinagawa Yoshihiro, Matsui Teruo, Tatsumi Hiroshi, Furukawa Toshi A
Department of Psychiatry and Cognitive-Behavioral Medicine, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
Psychiatry Clin Neurosci. 2007 Feb;61(1):78-83. doi: 10.1111/j.1440-1819.2007.01614.x.
Patients with the frontal variant of frontotemporal dementia (fv-FTD) exhibit deficits of executive functions. However, no single executive function task that might be used to detect the executive function deficits in fv-FTD patients has been established as yet. The frontal assessment battery (FAB) devised by Dubois et al. (2000) has been reported to be a quick and simple bedside screening test that is sensitive for differentiating between FTD and Alzheimer's disease (AD). The present study was conducted with the aim of ascertaining the reliability and validity of the Japanese version of the FAB among Japanese patients with fv-FTD. The Japanese version of FAB was given to patients with mild fv-FTD (n = 18) and those with AD (n = 18). The test-retest reliability was evaluated after a 3-week interval by the same interviewer. Data from the Wisconsin Card Sorting Test (Keio version: KWCST) were also collected to ascertain the validity of the FAB. The Japanese version of the FAB exhibited good internal reliability (Cronbach's alpha: 0.70, 95% confidence interval [CI] = 0.50-0.84) and good test-retest reliability (intraclass correlation coefficient: 0.89, 95%CI = 0.77-0.95). Significant correlations were observed between the total FAB score and the category achieved (r = 0.454, P < 0.05) and number of perseveration errors (number of errors that were perseverations; r = 0.719, P < 0.01) in the KWCST. A cut-off of 10 for the total FAB score yielded the highest sensitivity (85%) and specificity (92%) for discriminating between patients with fv-FTD and AD with the highest positive likelihood (12.0, 95%CI = 2.6-55.4). The Japanese version of the FAB offers promise as an easy and quick bedside screening test to distinguish fv-FTD from AD.
额颞叶痴呆额叶变异型（fv - FTD）患者存在执行功能缺陷。然而，目前尚未确立可用于检测fv - FTD患者执行功能缺陷的单一执行功能任务。Dubois等人（2000年）设计的额叶评估量表（FAB）据报道是一种快速简便的床边筛查测试，对区分FTD和阿尔茨海默病（AD）具有敏感性。本研究旨在确定日语版FAB在日本fv - FTD患者中的信度和效度。将日语版FAB施用于轻度fv - FTD患者（n = 18）和AD患者（n = 18）。由同一名访谈者在间隔3周后评估重测信度。还收集了威斯康星卡片分类测试（庆应义塾版：KWCST）的数据以确定FAB的效度。日语版FAB表现出良好的内部信度（克朗巴哈系数：0.70，95%置信区间[CI] = 0.50 - 0.84）和良好的重测信度（组内相关系数：0.89，95%CI = 0.77 - 0.95）。在KWCST中，观察到FAB总分与分类完成情况（r = 0.454，P < 0.05）以及持续错误数（持续出现的错误数；r = 0.719，P < 0.01）之间存在显著相关性。FAB总分的截断值为10时，在区分fv - FTD患者和AD患者方面具有最高的敏感性（85%）和特异性（92%），以及最高的阳性似然比（12.0，95%CI = 2.6 - 55.4）。日语版FAB有望成为一种简便快速的床边筛查测试，用于区分fv - FTD和AD。
