Lipton A M, Ohman K A, Womack K B, Hynan L S, Ninman E T, Lacritz L H
Alzheimer's Disease Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-8846, USA.
Neurology. 2005 Sep 13;65(5):726-31. doi: 10.1212/01.wnl.0000174437.73416.7b.
To determine the clinical utility of the Frontal Assessment Battery (FAB), a short test of frontal lobe functions, in differentiating frontotemporal lobar degeneration (FTLD) from Alzheimer disease (AD).
FAB total scores and subscores for 23 subjects with FTLD and 31 subjects with AD were compared for sensitivity, specificity, and positive predictive value. Concurrent validity of the FAB with the Mini-Mental State Examination (MMSE) and other scales was also assessed.
The FAB did not have positive predictive value for FTLD. Total FAB scores did not differ between the FTLD and AD groups. However, three subtests of the FAB (mental flexibility, motor programming, and environmental autonomy) demonstrated significant differences between the two groups. Total FAB scores correlated with scores on the MMSE, a more general test of cognition.
The Frontal Assessment Battery did not discriminate subjects with frontotemporal lobar degeneration from those with Alzheimer disease, though certain subtests may be helpful in differential diagnosis.
确定额叶评估量表（FAB）这一额叶功能简短测试在区分额颞叶痴呆（FTLD）与阿尔茨海默病（AD）方面的临床效用。
比较23例额颞叶痴呆患者和31例阿尔茨海默病患者的FAB总分及分项得分，以评估其敏感性、特异性和阳性预测值。同时还评估了FAB与简易精神状态检查表（MMSE）及其他量表的效度。
FAB对额颞叶痴呆没有阳性预测值。额颞叶痴呆组和阿尔茨海默病组的FAB总分没有差异。然而，FAB的三个子测试（心理灵活性、运动编程和环境自主性）在两组之间显示出显著差异。FAB总分与MMSE得分相关，MMSE是一种更全面的认知测试。
额叶评估量表不能区分额颞叶痴呆患者和阿尔茨海默病患者，不过某些子测试可能有助于鉴别诊断。
