Putnam F W
Unit on Dissociative Disorders, National Institute of Mental Health, Bethesda, Maryland.
Psychiatr Clin North Am. 1991 Sep;14(3):489-502.
The last decade has seen the emergence of solid research on MPD and the dissociative disorders, particularly in the area of diagnosis and clinical phenomenology. A number of other areas have been opened up or advanced considerably. The most notable of these include child and adolescent dissociative disorders; investigation of dissociative memory disturbances; studies of differential alter personality psychophysiology and switching; cross-cultural comparisons of MPD, possession, and dissociative states; and the contribution of pathologic dissociation to the symptomatology of other psychiatric disorders. Yet to be attempted, however, are prospective clinical trials and treatment outcome studies. In addition to clinical and theoretical insights, recent research provides strong evidence for the validity of the diagnosis of MPD. The repeated replication of a core clinical phenomenology demonstrates a construct validity equal to or superior to that demonstrated for most DSM-III/IIIR disorders. The ability of several independently developed instruments to blindly discriminate MPD patients from nondissociative disorder patients with high rates of accuracy supports both the construct and discriminant validity of the diagnosis; and as the astute clinical observations of the last century continue to be confirmed, MPD manifests an historical validity absent in most modern era diagnoses. In the future, arguments about the "reality" of MPD cannot confine themselves merely to attacking one aspect of the disorder but rather must confront the broad range of evidence supporting the validity and reliability of the diagnosis. The future belongs to multicenter studies, although intensive single-case and personal-case series will continue to make important contributions in some areas. The essential elements necessary to begin prospective multicenter studies are rapidly coming together. Already one multicenter structured interview study of clinical phenomenology has been completed and other studies are underway or near publication. As these collaborative research networks mature, even more ambitious studies will be attempted. Adequate funding remains the principal obstacle and must be creatively addressed in this era of budgetary shortfalls, particularly as several research networks cross international boundaries. Exceptionally gratifying is the burgeoning interest of large numbers of psychiatric residents and psychology graduate students in the dissociative disorders. Thanks to a decade of hard work, the next generation of clinicians and researchers will know a great deal more about these patients than the last.
在过去十年中,对多重人格障碍(MPD)和分离性障碍的扎实研究不断涌现,尤其是在诊断和临床现象学领域。许多其他领域也已被开拓或取得了显著进展。其中最值得注意的包括儿童和青少年分离性障碍;对分离性记忆障碍的研究;不同人格交替的心理生理学和转换研究;MPD、附身现象和分离状态的跨文化比较;以及病理性分离对其他精神障碍症状学的影响。然而,前瞻性临床试验和治疗结果研究尚未开展。除了临床和理论见解外,近期研究为MPD诊断的有效性提供了有力证据。核心临床现象学的反复验证表明,其结构效度等同于或优于大多数《精神疾病诊断与统计手册》第三版/修订版(DSM-III/IIIR)中的疾病。几种独立开发的工具能够以高准确率盲目区分MPD患者和非分离性障碍患者,这支持了该诊断的结构效度和判别效度;而且随着上世纪敏锐的临床观察不断得到证实,MPD展现出了大多数现代诊断中所缺乏的历史效度。未来,关于MPD“真实性”的争论不能仅仅局限于攻击该障碍的某一个方面,而必须面对支持该诊断有效性和可靠性的广泛证据。未来属于多中心研究,尽管密集的单病例和个人病例系列研究在某些领域仍将继续做出重要贡献。开展前瞻性多中心研究所需的基本要素正在迅速汇聚。一项关于临床现象学的多中心结构化访谈研究已经完成,其他研究正在进行或即将发表。随着这些合作研究网络的成熟,将会尝试开展更具雄心的研究。充足的资金仍然是主要障碍,在这个预算短缺的时代必须创造性地加以解决,特别是当几个研究网络跨越国界时。大量精神科住院医师和心理学研究生对分离性障碍的兴趣日益浓厚,这非常令人欣慰。经过十年的努力,下一代临床医生和研究人员对这些患者的了解将比上一代多得多。