[常规体外受精受精失败后卵胞浆内单精子注射（ICSI）和ISCI的临床结局：一项比较分析]

[Clinical outcomes of intracytoplasmic sperm injection (ICSI) and ISCI following fertilization failure in conventional IVF: a comparative analysis].

作者信息

Sun Li, Liu Ping, Quan Song

机构信息

Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China.

出版信息

Nan Fang Yi Ke Da Xue Xue Bao. 2009 May;29(5):993-5.

PMID:19460729

Abstract

OBJECTIVE

To evaluate the clinical outcomes of intracytoplasmic sperm injection (ICSI) in patients with previous fertilization failure in conventional in vitro fertilization (IVF) procedures.

METHODS

Between January 2007 and December 2007, 27 ICSI cycles following a previous fertilization failure in conventional IVF (group A) and 57 direct ICSI cycles using ejaculated spermatozoa (group B) were performed, and the clinical outcomes of the two groups were analyzed.

RESULTS

The fertilization rate per cycle of ICSI following a fertilization failure in conventional IVF was significantly higher than that of conventional IVF [(80.4-/+16.6)% vs (32.3-/+30.3)%, P<0.01]. The normal fertilization rate, high-quality embryo rate, clinical pregnancy rate per cycle in group A showed no significant differences from those in group B [(77.14-/+15.98)% vs (70.59-/+21.53)%, (28.68-/+23.86)% vs (27.18-/+23.97)%, and 48.1% vs 54.4%, respectively, P>0.05]. The cleavage rate and transferable embryos per cycle in group A were significantly higher than those in group B [(96.66-/+6.55)% vs (92.33-/+19.41)%, 2.67-/+0.56 vs 2.12-/+0.57, respectively, P<0.05].

CONCLUSION

ICSI after a previous fertilization failure of conventional IVF may significantly improve the fertilization rate and clinical outcomes of a second IVF-ET cycle.

摘要

目的

评估在既往常规体外受精（IVF）程序中受精失败的患者行卵胞浆内单精子注射（ICSI）的临床结局。

方法

在2007年1月至2007年12月期间，进行了27个既往常规IVF受精失败后的ICSI周期（A组）和57个使用射出精子的直接ICSI周期（B组），并分析了两组的临床结局。

结果

既往常规IVF受精失败后行ICSI的每个周期的受精率显著高于常规IVF [（80.4±16.6）%对（32.3±30.3）%，P<0.01]。A组的正常受精率、优质胚胎率、每个周期的临床妊娠率与B组相比无显著差异[分别为（77.14±15.98）%对（70.59±21.53）%，（28.68±23.86）%对（27.18±23.97）%，以及48.1%对54.4%，P>0.05]。A组每个周期的卵裂率和可移植胚胎数显著高于B组[分别为（96.66±6.55）%对（92.33±19.41）%，2.67±0.56对2.12±0.57，P<0.05]。